01 Oct 2017
Home
File List, RICO
1988 Steere says Lyme is like a B cell leukemia
Assoc Blogs-n-Webs:
TruthCures.org
badlymeattitude.com/
immune2lies.com/
researchfraud.com/
may12.org
meadvocacy.org/
truthbetoldx81
lymecryme
CrymeDiseaseNorway
crymedisease
theothersideofthestretcher
rjspiritualityandtuth
LymeTruthSite
JC-LilnkedIn
KD-Linkedin.com
LD-LinkedIn
JC-academia.edu
KD-academia.edu
CDC "SPIDER"
Fungal Exosomes Inhibit Apoptosis
IDSA:
"Vaccines serve the mfgs, not their victims"
RICO_filed_USDOJ
BlumenthalAntiTrust Lawsuit
Exosomes, Blebs
Spirochetal_Dementia
PDFs
CDC Admits Fraud, 2016
Dattwyler, 1988
Golightly, 1988
Dressler,
1994
BarbourFish, 1993
Dearborn,
1994
BarbourFishpdf.pdf
Pathogenic Fungi
Bush's warcrimes, Oct 2000
Trainer
170708 |
| |
Bogus Report on the Supremes from a Harvard Law CFR-er
▲ To which we say, "Bullsh*t,
Sir. We can figure it out. The nation is the
rebellion... against the likes of yourself."
Glenn
Greenwald:
Why Is a US
Army Brigade Being Assigned to the 'Homeland'?
Good news, Mr. Greenwald. They've never once made a weapon
that they did not deploy, either
accidentally or on
purpose. Having failed to scare us with the
911 thermate ruse, having lost Iraq,
having rapidly rescued Russia in response to their international
criminal antics, having been unable to secure the Afghan-Caspian
pipelines and minerals for Enron, the surge having failed to secure
for Baghdad oil contracts and a commercial oil-banking zone
(remember Wolfowitz was to have that position, World OilBank Viceroy
of Baghdad), having failed to convince us Guantanamo was cool,
John Rowland's TREA
Custodial Democracy scheme
having flopped (in bed,
as usual), making hysterical noises about pandemic flu (only to have
it revealed that it will be a swine flu if there is ever a natural
flu pandemic, since a lesser mutation allows it to "take" to human
tissue) didn't electrify our hysters, Americans are simply
going to shoot the treacherous cops and troops and troopers in the
streets. It's going to be Civil War II, on top of Great
Depression, II, because people have no respect for "law enforcers"
whatsoever.
They showed us plainly and clearly, that they really were pigs -
groveling, petty, trash-wallowing low-lives - all along.
Watch this video:
Everyone in
CT should study this video (Judge Kaplan, State Troopers =
INSANE!!) RAILROADED, crooked Corrupticops,
prosecutors and "judges"...
Who could have
any respect for that kind of trash, after Abu Ghraib and tasering
babies?
It's gonna be great!
And read this:
http://www.counterpunch.org/hudson09252008.html
▲There never was a better smack upside
the Palinite
Neanderthals' Fake-Christian heads, but ya know what it won't
matter because not only do people delusionally worship the
uppercrust system (who abuse them), they worship their groveling
low-life existence and they watch plenty of shoot-em-up cops shows
and they think they're all "it" and they are all it,
and they will be all it and it's gonna be brutal
and great. The banksters (psychiatry)
taught them all they know about "I-Love-MEEEee" and others-hate. "Clean
Slate:"
The Future of the United States Howard Storm (Clean
Slate)
"If the United States
continues to exploit the rest of the world by greedily consuming the
world's resources, the United States will have God's blessing
withdrawn. Your country will collapse economically which will result
in civil chaos. Because of the greedy nature of the people,
you will have people killing people for a cup of gasoline. The world
will watch in horror as your country is obliterated by strife. The
rest of the world will not intervene because they have been victims
of your exploitation. They will welcome the annihilation of such
selfish people."
http://www.near-death.com/experiences/storm03.html
7"(P)To
the degree that she glorified herself and (Q)lived
sensuously, to the same degree give her torment and mourning;
for she says in her heart, '(R)I
SIT as A QUEEN AND I AM NOT A WIDOW, and will never see
mourning.'
8"For this reason
(S)in
one day her plagues will come, pestilence and mourning and
famine, and she will be (T)burned
up with fire; for the Lord God who judges her (U)is
strong.
And now back to the program:
Anthrax Dirty Bomb ◄ Says Pfizer's Mike Dunne, "Pfizer
does not make Trovan any more" because they "can't get the starting
materials," unaware, is Mike Dunne (because he is not a chemist as
head of the Pfizer Infectious Diseases Division! over on the New
London, CT side of the Thames), that I am an actual chemist and
would know that that statement is baloney.
I thought you would all find that humorous because of:
http://www3.niaid.nih.gov/topics/BiodefenseRelated/default.htm
Hilarious. Google TrovaZit.
======================================================
http://www.youtube.com/watch?v=1OTM8Y3a5zQ ◄ Bailout Funny
======================================================
Turn the Corner: http://www.youtube.com/watch?v=XnRrdtusWdw
You can't turn the corner until you back up to where the crooks took
a wrong turn and have been publishing garbage ever since. And
that wrong turn was Dearborn. It's amazing that people like
Joe Burrascano thinks he can devise new "check lists" and that's
going to be scientific. You have to understand the scientific
fraud and you have to expose it so that it gets prosecuted for the
crime that it is.
Yikes. ILADS.org is hopeless.
==================================
Says Willy Burgdorfer, discoverer of the Lyme Relapsing Fever
spirochete, in the movie, UNDER OUR SKIN (Under
Our Skin trailer),
"After 30 years we have NOTHING"
(You have to see the movie because you just have
to see the look of total disgust on his face. It's great.)
It's actually worse than nothing. The
Lyme crooks inhibited discovery in all diseases, including HIV
and cancer, by lying about "Lyme
disease" and OspA
or the LYMErix and ImmuLyme vaccines.
See more about these crimes in the white box below the pink (fairies)
box below.
I'm gonna show ya
CHAPTER 15,
PLUM ISLAND SLYME (OspA or
special fungal Pam3Cys) and
IMMUNE-SUPPRESSION
TLR2 and HLA
(antibody production) down-regulation and auto-kill caspase &
TNF inhibition inhibition = Plum Island's fungal secret antigen
treasures (stealth disablers).
CHAPTER 28, The HISTORY of
relapsing fever
33 years of crime and incompetence brings us back to
1975...
Says CDC officer Alan Barbour:
"We treat spirochetal
diseases with other spirochetal diseases to cause a fever because
antibiotics don't work."
This seems like an amazing!
choice of treatment for a disease that does not exist or is easily cured by
antibiotics, and especially, for a disease that has no brain residua.
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=373079&blobtype=pdf
By CDC Officer Alan Barbour, in 1986, The Biology of Borrelia Species:
"The propensity for borrelia to go to the
brain of infected mammals
suggests that the relationship between these spirochetes and neural tissues is
not trivial. Further study of this attraction and the interaction that follows
may reveal the basis for the significant nerve and brain involvement in Lyme
borreliosis"--
Oh.
More about the mechanisms of immune suppression below this pinko
(cuz that's what fascist authoritarians are, pinko commie
fairies with no dicks) box:
"NO" TO THE BAILOUT
If we sink, the banksters are going down with us.
"Paris-based financial analyst Max Keiser on the US financial
meltdown says, "For the average American, this is what they will
experience. The price of food and oil are going to skyrocket due to
hyperinflation. The only way they can possibly pay for all these
bailouts is to inflate the money supply. This means hyperinflation
in America like you had in Germany in the 1920s. This is what the
average American will experience: destitution, poverty, social
unrest due to flagrant bank mismanagement - and it could have been
avoided. But unfortunately the banks in the USA are run by greedy,
insane private marketers and this is the result.”
http://www.presstv.ir/detail.aspx?id=70490§ionid=3510203
http://www.youtube.com/watch?v=vFU8DM2NjCk
License plate # 5-7543, in case anyone was wonder how
duh
DCF could possibly be so stupid, lame, lazy, evil, retarded and yet dare
to complain about how tough their job is:
http://www.youtube.com/watch?v=ycI8tZrcaFk&feature=related
◄Yet another one.
http://www.youtube.com/watch?v=lyI1hPdxNhU&feature=related ◄ And
this one was caught taking a leak while hiding from work in a State
park, LOL.
http://www.youtube.com/watch?v=s8qCXm9zewg&feature=related
◄Yet another one.
http://www.youtube.com/watch?v=nxw956i2m3Y&feature=related ◄ And
another one. (This appears to be a police officer scoping these
idiots out.)
That's 5 separate DCF cars, LOL, all snoozin or peeing in the State
parks.
- - - -
If we are
experiencing an epidemic of asthma (and autism, hint, hint) in children, and asthma represents
one end of the immune response to inhaled fungal antigens (immune
suppression like the Chronic Fatigue Syndrome being the other end of the
spectrum), then let's suggest that some kids are immune suppressed
without anyone knowing it. Thus, all kids should be prescreened
for immune status before being given any vaccination.
We know the CDC is
full of crap, and that they have said that they are aware of the
vaccines-associated autism outcomes, but, according to the CDC, this
damage is "a calculated risk."
CDC does the
calculating and they have calculated that your kids are
worthless experimental lab animals, much in the same manner as
Allen Steere treated Dr. Michael A. Schwartz.
The people can't get past the
porkers.
So
bizarre is this state, that I had to listen to a lecture by a staff
member of State Representative James Amann's (D- Milford) whose name
also happens to be Kathleen. Amann's Kathleen tells me she is a
chemist and that she knows all about the testing for "Lyme
Disease." That surprises me because she would not be a chemist
working for James Amann if that were true. Amann's Kathleen tells
me she knows more about Lyme disease than I do because her mother
had it and that her mother got better from it. Usually people are
criticized when making general exclamations about medical conditions
on the basis of a relative's brief experience with it. In fact, the
likes of Amann's "chemist" are the very scary tards the Lyme
criminals warn us about.
Amann's
full time job is to be a fund-raiser for the Multiple Sclerosis
Society of America. He gets a percent of the money he raises.
Thus, he is so good at selling himself and his retarded bullshit, he
not only became a politician, he became the Connecticut State
Speaker of the House. The unions elect the democrats because
republicans have generally, in the past, been against big government
and unionized screw-driver-turners. The republicans in Connecticut
keep a low profile except for when they want to create the
emergencies of "bad parents and criminals" in order to defraud Uncle
Sam over how much "bad" goes on in this state, in order to not raise
CT State income taxes. It's a simple formulary where anyone who is
not rich or a State employee union member is fodder for this human
hamburger processor. The mere people have the same function they
did in Machu Picchu. The mere people are the materiél
and maintenance of slaughter needed to keep the political gods and
the union gods happy so it will rain dollars from China.
Chapter 22, CRYME
DISEASE.
Everyone in
CT should study this video (Judge Kaplan, State Troopers =
INSANE!!) RAILROADED, crooked Corrupticops,
prosecutors and "judges"
Corrupticut- Home of the Chocolate Burger.
We're a human
hamburger processing state and Black is our favorite flavor.
The New World Order is designed to
terrorize the common people- take it from
us, in Corrupticut.
Repressed Speech at Quinnipiac
(LOL, Everyday Life in Corrupticut)
The cops and duh DCF brutalized this man's kids because he won a
police brutality lawsuit against the State Troopers
The details of the case are here.
http://starkravingviking.blogspot.com/2006_03_01_archive.html
◄"Judge" Howard "Cockadoodle-do"
-sayin, "El-Stupido" -sayin, Violin-playin -
Scheinblum at the March 2006 Hartford, CT, Judiciary
Committee Hearing where Steve and I took this next videotape:
Representative
Bill Dyson interviews future Judge Randolf- "It's a
PERCEPTION problem."
Randolf,
"I never saw a white kid from Wesleyan charged with
possession with intent."
That's
right. Everyone who is not a union member or a wealthy person
else is "BAD," but the crazy psycho cops and the crazy DCF are
the only "GOOD" people- yet they commit the worst crimes and
happen to all Party and Screw
together.
WHEREUPON, I got a letter from the Capitol Police....
REP. HOVEY: Thank you, Mr. Chairman. Before you, I'm not sure what
the protocol is, do you want to close the public hearing? I have a
comment I want to make.
REP. LAWLOR: Oh, sure, I can close the public hearing. No problem,
it's okay.
REP. HOVEY: Okay, I just wanted to say that I respect the,
respectfully object to the delay in the votes on these judges
because it's my understanding that the delay is due to one of the
nominees specifically.
And, from my perspective, we've appointed and appraised judges who
have had significant issues with demeanor.
They're arrogant, pretentious and even dishonest, and that we have
recently approved a judge who knowingly put children back into
harm's way instead of using
their judicial latitude to protect these children.
And the particular individual that we had earlier today, I believe
the terms willful neglect and this or that about their circumstance,
personal circumstance.
And what I would say is, someone who sits on this Committee with a--
[Whereupon, the hearing was adjourned.]====
“Whereupon, the hearing was adjourned.”
???
======================================================
Connecticut has more children in jail than
anyplace else on earth and 82% of them are Black or
Latino. Corrupticourts
"judge" Jonathan Kaplan says kids belong to the State, first, that
parents have "no divine right" to their children, and that
Irish people are bad
because they don't like British colonial dictatorship (much like the
early USA and present day Palestine, I remind). "Judge" Howard
Scheinblum called a Latino person "El Stupido," in court and denied
him a public defender (illegal). Other defendants are asked to
climb on a table (in court) and crow
like a rooster, in order to get a reduced sentence.
Illegal wiretapping and illegal consults with "judges" who have
absolute zero experience in the Corrupticourts have long been a
Corrupticourts tradition...
http://www.topix.net/forum/source/hartford-courant/T50TF72FSEC9OIUAA#lastPost
Blumenthal is the STATE's attorney, not the people's
attorney...Re: Challenging Atty Gen Blumethal
http://www.starkravingviking.blogspot.com/ Steve (The
Viking) is very pissed and rightfully so.
Clarification: CT Attorney General Richard Blumenthal works
for the criminal State employees (UConn, State Troopers, DCF, and
DMHAS), who committed the Lyme and other infamous crimes. So, Connecticut could
be sued in a class action, but Blumenthal would have to defend the
State in that class action,... but he can't since he
sued the Lyme
criminals.
LOL. It's tough to figure out unless you're some creepo lying
lawyer or psychiatrist, always looking for an angle or a way to
screw people.
(I'm a scientist. I just give people the facts, because facts
are intended to mean something; or are the gift
of truth. The fact that facts are intended to
mean actual, well, things, is something lawyers and psychiatrists
would never understand, since scientific facts are so different from
the hardwiring of their dominant lying left brains. In a word,
lawyers and psychiatrists are Aspergery with a fairy twist.)
Think about it. How many times were State of Connecticut
employees, including the head of the
DCF and a "forensic
psychiatrist for the State" given the proof that Lyme was a
crime? 'Instead of doing what they're paid to do, protect
people- not just sick people, but all people- from such crime?
Think about how many State employees perjured themselves to protect
Yale's perjuring, lying, malpractitioning pervert, James Phillips,
from a malpractice lawsuit. You know it is true since how the
hell else would I have been falsely criminally charged with being a
"dangerously intelligent"
"chemist, like Ted Kascynski?"
Think about it: What year did Yale's Durland Fish and Edward
McSweegan conspire to defraud
Uncle Sam on their work time, using their dot guv and Yale email
and work time? 1995 was right after the definition of "Lyme
Disease" had changed, in October, 1994, at Dearborn.
Jan 31, 2001, I gave this presentation to the
FDA Vaccine Committee:
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf
◄ That was the entire Lyme Cryme in a Nutcase State shell.
Allen Steere changed his own former diagnostic standard from Lyme as
a Relapsing Fever organism to Lyme as only a late arthritis in a
knee- the disease with no fatigue and no brain signs. So, the
State of CT could be sued in a class action.
This is all very creepy and very evil, but very typical of
Corrupticut. None of the men have any balls here, and all the
MDs would like to be famous Yale ass-kissers.
They don't care that Yale committed the biggest
medical crime in human history, that affects people on nearly all
the inhabited continents and negatively affected research in nearly
all chronic and deadly diseases, including cancer.
If any MDs in Corrupticut cared about this cryme, they would say
something about it. Notice none of even the ILADS.org MDs in
Corrupticut say anything publicly or to the USDOJ that Lyme is a
RICO and scientific fraud
cryme committed by Allen Steere in
Europe and perpetrated in Corrupticut, mainly by
Yale's Robert Schoen.
Alice Walker:
What Our
Country Desperately Needs is a Leader Who Loves Us
Sorry, Ms. Walker, I hate to inform you that Corrupticut is also the
most racist hateful, vain, incompetent, selfish and
stupid state in the Union. If we had any leaders that love
Americans, well, this website would not exist. And this is my
third website. The first one went up 8 years ago.
Love means "do;" take action.
=============================================================
I alleged long ago, since I am a chemist, that the
blot smudging in
LYMErix vaccinated people could be due to multiple antibodies being produced
to the various globulated forms of LYMErix in a vial, since I knew it would
be next to impossible to perfectly micellize the lipoprotein OspA such that
single molecules of it would be injected into LYMErix victims.
And viola, whaddya know, the Korean
chemists who blasted (Mass Spec) the AIDS gp120 and gp41 "glycolipids"
agreed:
Here's another report saying the same thing:
http://www3.interscience.wiley.com/cgi-bin/fulltext/120763430/PDFSTART
(◄like LYMErix and E.
coli's "Lipid A")
"A major problem of investigating the interaction of lipoprotein
with lymphocyte membrane was its tendency to form aggregates..."
LOL, resulting in the unreadable Western Blots or the blot-smudging
in LYMErix vaccination, rendering Western-Blots unreadable, and thus
the LYMErix results a
TOTAL FRAUD.
Now, none of this stuff is in Pam Weintraub's Lyme book, because I hadn't
published it yet.
Watch the animation:
http://www.youtube.com/watch?v=RO8MP3wMvqg
HIV vaccine with
Pam3Cys or something a lot like LYMErix stuck on it:
◄ This is supposedly how OspA lies in borrelia. The lipid portion appears to
be buried in the spirochete membrane. I do not not know how the glyco-lipids
of HIV lie (the protein portion appears to be scrambled into the lipid portion),
or even if for certain they're Pam3Cys, although I have no information that
they're not. I only have information that OspA and Pam3Cys have the same
linear chemistry structure (but this is no predictor of presentation; the DNA
can be sequenced, in other words).
From:
https://www.aidsreagent.org/program_info.cfm
I'll be dipped if I can find a proper linear structure of this
online. I guess that's because they can't X-ray diffract the
real structure with the lipids stuck to it. Can't find it in
the patents and I can't find it online in the journals (free
journals).
http://www.google.com/search?hl=en&q=HIV+gp120+structure+cysteine+tripalmitoyl&btnG=Search
Pam3Cys as adjuvant (Rockefeller University,
1992):
http://www.ncbi.nlm.nih.gov/pubmed/1478779 (this is
included in the Plum Island chapter)
http://metab2mesh.ncibi.org/index.php?term=tripalmitoyl+cysteine&qtype=substance
PLEASE SEE MORE OF THIS DATA BELOW THE WHITE BOX
============================
THE FOLLOWING IS TO BE USED AS AN INDICTMENT AGAINST YALE'S
ROBERT SCHOEN and HARVARD'S ALLEN STEERE FOR RESEARCH FRAUD AND
RACKETEERING. I am still working on this, summarizing
all the outcomes of the fraud- the
lying to the FDA
about the outcomes of LYMErix and changing the diagnostic standard
of Lyme, knowing full-well, the only reliable antibody
was Bb specific band 41 or
flagellin.
The
rapists
Kaiser-Permanente, Allen Steere at the "Academy
of Insurance Medicine",
Yale, SmithKline,
AIG, Mortimer Zuckerman,
Anthony J. Walton, Philip
Morris, and the cowardly, do-nothing staff of the CDC, NIH and FDA
who participated in "theft of honest services."
Remember,
now, The Lyme crymes is a
False Claims Act
case against Yale University.
What we are going to find is that Yale, by not reporting the
adverse events to LYMErix (or bothering with these patients at
all),
missed the common link to all chronic,
devastating and deadly illnesses: ALS, MS, cancer, CFIDS/FM,
Leukemia, what was wrong with the HIV vaccines, etc... and
that link was OspA- Yale's vaccine. OspA is a fungal (mycoplasmal)
antigen that turns off the immune system through various
mechanisms. This allows common latent viruses of all kinds
to become unlatent. The latently infected cells do not
autokill as they should when the common latent viruses start
replicating (the normal mechanism of immunity), and the fungal
Pam3Cys antigen OspA, turns off antibody production against
similar antigens.
1) Yale never had a Lyme
vaccine (it was not proven to prevent Lyme). 2) Yale claims the
Dearborn
method is Lyme, when they have a truly
validated test that proves
otherwise. 3) Yale's Robert
Schoen never
reported to the FDA that he could not read his Western Blots in
LYMErix vaccinated people, so he lied to the FDA about the
efficacy and safety of LYMErix,
Yale's patented vaccine.
4) Schoen instructed MDs to
blow-off LYMErix systemic disease (immune
suppression) victims, but reveals the RICO method in the
Munchausen's book (libel).
This publication by Schoen is the single most significant
reason the crime should be charged against Yale;
L2 Diagnostics and
PolyGenomics. Schoen knew LYMErix was never a vaccine, he
knew Dearborn was bogus, and he worked with Dave Persing on the
primary or central RICO
patent, but never told anyone the reason OspA and B were
left out of the standard at
Dearborn.
Gary Wormser reporting the blunting of the immune response in
OspA vaccinated
animals:
http://www.ncbi.nlm.nih.gov/pubmed/10865170?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
"OspA interferes with the response of lymphocytes
to proliferative stimuli including a blocking of cell cycle phase
progression."
Says Dave Persing, formerly with the Mayo Clinic, and owner of
the central
Imugen-Corixa-L2 Diagnostics RICO patent (This is a patent
for a modified OspA vaccine-as-an-adjuvant, but they never told
the FDA they knew there were problems with LYMErix. The
patent was applied for in May, 2001, when LYMErix was still on
the market- but none of the evil murderous bastards said a word
to the FDA about this):
"Accordingly, the methods of the invention provide a
powerful and selective approach for modulating the innate
immune response pathways in animals without giving rise to
the toxicities often associated with the native bacterial
components that normally stimulate those pathways."
http://patft.uspto.gov/6,800,613
5) Yale claims their is no such thing as
congenital Lyme,
while having performed autopsies or reported about several
congenital Lyme deaths and abnormal infant outcomes. 6) Schoen is
playing
a DNA/RNA primers shell game.
The RICO patent Borrelia strain was identified with the proper
RNA methods, but these correct primers have never been used to
assess treatment outcomes. 7) They committed this crime with clear intent to cause harm,
due to all the obvious slander,
perjury,
stalking, wiretapping, and
harassment, and especially, the Munchausen's accusations.
From
the August, 2005 complaint to
HomeLame Stupidity Secretary Jerkoff:
14) The Lyme
disease racketeering crime involved insurance companies’
denial of care for chronic Lyme, which was also masterminded
by Allen Steere when he defrauded the public by stating that
late chronic nervous system Lyme was “some psychiatric
disorder,” and wrote the “bogus
article,” “Overdiagnosis [sic] of
Lyme disease.” In this “bogus” (a
word used by Yale’s Durland Fish in correspondence with the
NIH’s Edward McSweegan) scientific report, Steere also used
the bogus high-passage
strain G39/40, to not find Lyme. Not
finding Lyme saves insurance companies a great deal of
money, since the relapsing-remitting treatment for this
relapsing borreliosis, Lyme disease, which results in a
Multiple Sclerosis-like syndrome according to Allen Steere
(1991 Rheumatology News) costs $12,000 a month,
minimally, as is the wholesale cost of the drug (the
discounted price, where the pharmacy makes no profit).
The spin is to say Lyme victims are just CRAZY and
don’t have a real illness (Chronic Fatigue Syndrome and
Fibromyalgia are considered psychosomatic illnesses).
However, the
malpractice treatment of late nervous system Lyme, which
is treatment with psychotropics, increases the dementia.
This malpractice is even clearly against the
American Psychiatric
Associations’ Guidelines for the treatment of a
delirium, since these guidelines clearly state
“Medications
for psychiatric disorders can be both the cause of delirium
and exacerbate or contribute to delirium from other causes.”
8) Yale continues this crime because of the
criminal liabilities
associated with admitting their testing fraud (leaving OspA and B
out of the diagnostic standard by using bogus strains in
Europe). They still publish bogus articles, ie.,
Klempner, 2001, on the
Standard-of-Care of Lyme, which is the basis for the 2001 and
2006 "Infectious Disease Society of America's" "guidelines" on a
"disease" that Gary Wormser and Mark Klempner have revealed have
generally no fatigue or delirium in 2005: a late Lyme arthritis
in a knee. By and large, the only people who test positive
to the new, bogus, 1994, CDC, Dearborn, Michigan,
hypersensitivity reaction "case definition" are the late Lyme
arthritis people, as explained in the
RICO complaint to the
USDOJ in the summer of 2003.
http://www.journals.uchicago.edu/doi/pdf/10.1086/432733?cookieSet=1
Here is proof that
Gary Wormser knows that the current (Dearborn
IgG) testing for Lyme
only detects 9 of 59 patients
according to Steere's IgG criteria:
(9/59) = 15% ??
Read carefully what Wormser says in this ▲report:
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=266355&blobtype=pdf
Wormser says he is assessing Steere's IgG
recommendation for the CDC to adopt (Dearborn), and that it was
NO GOOD. Yet it was
adopted by the CDC anyway.
Who approved this standard, even though none
of the labs agreed?
For Wormser to report in the IDSA guidelines
and in the movie, Under Our Skin, that one has to have a positive
test for Lyme, means he has
published scientific fraud. Similarly, CDC
says their testing for Lyme is "valid," when it is hardly valid, if only 15 %
cases of Lyme are identified by IgG.
You can see the link to the YouTube
clip of UnderOurSkin where Wormser says a person needs to have a
positive test or a rash in order to have Lyme,
here:
http://www.actionlyme.org/MOMS_CAN_GIVE_LYME_TO_BABIES.htm
▲At the bottom of the page.
The ALS
outcome of Lyme is clearly deadly, but the Western Blots of
those Lyme-ALS victims would never have tested positive to the
Steere/Dearborn-Lyme-is-only-a-reactive-arthritis-in-a-knee-Method.
Hence, these will be murder charges.
Lou Gehrig's disease is also
linked to fungal infections (Mycoplasma and OspA), as is the
case with chronic Lyme and the Multiple Sclerosis outcome:
MEDLINE LINK. These chronic illnesses, these New Great
Imitator outcomes, seem to be the result of the immune
suppression caused by the shed fungal antigens, like OspA.
9) Yale and UConn performed a
pediatric trial
with LYMErix - knowing it was never a vaccine - in Europe on Czech
children, without informing the Czech's that there is no OspA
from B31 in Europe. This is technically known as
"assault." The pediatric LYMErix trial had no value
other than to determine how badly the children would be damaged.
10) The reason the
RICO cabal caved was
because in the movie, UnderOurSkin, shown in New York City on April 26, 2008,
Yale's Eugene
Shapiro flat-out lied his face off about congenital Lyme.
This made Blumenthal's staff utterly FURIOUS.
AIG is a supporter of this
RICO clique.
Kaiser-Permanente
is a founder of the ALDF.com RICO
enterprise at New York Medical
College, in Valhalla, New York.
The FDA formally
disclaims their responsibility to look at the data BigPharma
sends them, to see if the perps
followed FDA's
testing rules (to see if their products actually do what
they claim, or in the case of LYMErix, the FDA did not check the
validity of the Dearborn
method).
Not one
single MD group or association anywhere in America says a single
word about this RICO testing crime, despite the CT Attorney
General's office suing the
bastards, and the agreement looks like the perps want to
avoid criminal charges.
LOL. It was over
congenital Lyme.
(4+ cases reported by Yale, Steere and Willy Burgdorfer)
Not one
single newspaper has covered the story of the Lyme testing
fraud. Not one single newspaper interviewed Allen Steere
and asked him why he went to
Europe with a bogus "high-passage" strain to invent the new
Dearborn (CDC) diagnostic standard- the one Gary Wormser
reported only detected 9/59 cases of Lyme.
Not one
single newspaper interviewed anyone at
the CDC and
asked them about the meaning of their MHC-restricted antibodies
claims in their 1992 patents with SmithKline in Europe.
Not one
single medical journal or medical society in the entire USA or
Europe ever had a scientific team look into our claims that
changing the diagnostic standard for Lyme (to make it only a
late Lyme arthritis in a knee) was scientific fraud, despite the
Blumenthal lawsuit.
Not one
single newspaper or medical society looked into and reported
that Yale missed all the immune suppression outcomes caused by a
fungal vaccine (OspA or LYMErix) and the auto-vaccination or
auto-tolerization process of
spirochetal blebbing,
that resulted in all the New Great Imitator outcomes
or the immune dysregulation/suppression outcomes (they are the
same), or
considered what this crime's effect might be on discovery in
other chronic illnesses, including cancer and HIV.
http://www.jimmunol.org/cgi/content/full/170/1/508
Prior exposure to LPS both in vitro and in vivo can lead to
desensitization of immune cells to subsequent
challenge with LPS, a phenomenon that has been
referred to as "endotoxin tolerance."
(There is more of this kind of data below this white box;
the issue for chronic Lyme is tolerance to fungal infections of
the blood, like mycoplasma and Candida albicans, or tolerance
that leads to the phenomenon of common virally infected cells
becoming un-latent, and then not auto-killing, eg, Epstein-Barr,
cytomegalovirus, HHV-6 etc, which most people with chronic
neurologic Lyme have.)
You all
see this data nowhere else in the world, correct?
◄"On occasion, these atypical-appearing large lymphocytes have been
misinterpreted in biopsy by several laboratories as cells of a malignant
lymphoma or leukemia. Bb antigens, then, may stimulate growth of
immature lymphocytic suibsets in some target organs, as well as in the
cerebrospinal fluid (Szyfelbein and Ross 1988). Usual bacterial
infections do not produce such lymphocytic infiltrates in tissue.
These immunoblastoid cells in Bb infections at times resemble those found in
Epstein-Barr virus infections. Does Bb reactivate latent virus
infections in tissues? Do some tick inocula harbor simultaneous
infectious agents (ixodid ticks can harbor Rickettsiae, Babesia microti, and
Ehrlichia bacteria, in addition to Bb), producing multi-agent infections in
some hosts? Further studies can clarify these issues by mans of
tissue-based molecular probe analysis." -
Paul Duray, NCI, NIH,
Ft. Detrick, at the 1992 Cold Spring Harbor Crooks' Conference, published in
Steve Schutzer's Lyme Disease: Molecular and Immunologic Approaches.
http://www.amazon.com/Lyme-Disease-Immunologic-Approaches-Communications/dp/0879693770/ref=sr_1_2?ie=UTF8&s=books&qid=1214848669&sr=1-2
I think it is so frickin funny
that not a single MD in America has any balls or brains.
Not even when you put a whole bunch of them together. Not
even as a group do they have a ball or a brain cell.
THAT'S America.
Check it out:
http://www.ncbi.nlm.nih.gov/pubmed/15385250?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Cerebrospinal fluid CD4+ T cells from a
multiple sclerosis patient cross-recognize Epstein-Barr virus
and myelin basic protein.
Institute of Immunology,
Rikshospitalet University Hospital, Oslo, Norway. trygveho@labmed.uio.no
Epstein-Barr virus-specific CD4+ T cells
could be involved in the pathogenesis of multiple sclerosis,
provided they can gain entry to the intrathecal compartment. The
authors have previously demonstrated that cerebrospinal fluid T
cells from multiple sclerosis patients recognize autologous
Epstein-Barr virus-transformed B cells. They now report that
CD4+ T cells specific for the Epstein-Barr virus DNA polymerase
peptide EBV 627-641 were present in the cerebrospinal fluid from
one of two multiple sclerosis patients, and that a high
proportion of these CD4+ T cells cross-recognized an
immunodominant myelin basic protein peptide, MBP 85-99. In the
observed patient, the proportion of EBV 627-641-specific CD4+ T
cells seemed to exceed 1/10,000 in cerebrospinal fluid, compared
to approximately 1/100,000 in blood. These findings prove that
Epstein-Barr-virus specific CD4+ T cells can gain access to the
intrathecal compartment, and suggest that Epstein-Barr
virus-specific CD4+ T cells could target myelin basic protein in
the central nervous system.
Lyme and Multiple Sclerosis?
Who is Roland Martin?
Multiple Sclerosis, I note, is not an autoimmune arthritis in a
knee.
Chronic Lyme and LYMErix Disease are all the New Great Imitator
immune suppression outcomes that are associated with Pam3Cys or
OspA. That's why LYMErix came off the market. It
wasn't because of poor sales, but because it gave people immune
suppression outcomes, just like the ones into which chronic Lyme
progresses (ALS, MS, Chronic Fatigue, MS, blood cancers,
multiple myeloma, Fibromyalgia...).
The immune suppression caused by
chronic Lyme (Relapsing Fever with a mycoplasmal twist) result
in the activation of latent viruses of all kinds, like
Epstein-Barr, leading to the likes of cancers and Multiple
Sclerosis, since viruses are well-known to be associated with
the development of cancers.
That's why Ft. Detrick and the National Cancer Institute are
basically interrelated, which was how Paul
Duray came into the picture, because he works for both.
Duray actually worked with Steven Hatfill.
CDC Officer and ALDF Bioracketeer
Alan Barbour explaining: "Immune System Overhwhelmed," US Patent 6,719,983-
"2.1 Methods of Treatment
"An important aspect of the invention is the recognition that Borrelia VMP-like
sequences recombine at the vls site, with the result that antigenic variation is
virtually limitless. Multiclonal populations therefore can exist in an infected
patient so that immunological defenses are severely tested if not totally
overwhelmed."
- - - - - -
"He finds
that during the early stages of infection, B. burgdorferi avoids immune
detection by decreasing its expression of surface proteins or cloaking
its expressed surface proteins under a layer of slime. "It's using some
sort of stealth-bomber-type mechanism," he says. Or, using another
diversionary tactic called blebbing, the spirochete can pinch off bits
of its membrane in order to release its surface proteins. Explains
Barbour: "It's like a bacterial Star Wars defense program," in which
released surface proteins might intercept incoming host antibodies
keeping the spirochetes safe from immunological attack." --
1996, The Crooks.
Mycoplasma adhering to, embedding into erythrocytes
◄ Go here for more excellent graphics (Click on image to view larger version)
http://iai.asm.org/cgi/content/full/76/1/71/F1
FIG.
1. Scanning electron micrographs of sheep (A) and chicken (B)
erythrocytes after in vitro infection with a clonal derivative of M.
gallisepticum strain Rlow. The arrows indicate
mycoplasmas or imprints of mycoplasmas appearing to sink into the
erythrocyte surface.
I
would say mycoplasmal infections distort the shape of
erythrocytes, no? Anyone with Chronic Fibrofemzalgilyme
will tell you that we have normal hemoglobin but we're so
tired. So how could our blood cells
possibly be getting adequate oxygen to our cells??
Since we know we're not
making up our symptoms, we knew there would be discovered
scientifically valid explanations or at least scientifically
scientific and not sooth-sayin crystal-ballific
explanations.
Right. And those are just
erythrocytes. I'm thinking IDSA is going to be somewhat
regretful for having deployed the Quija-Boarders, the
American Psychiatrogenic Ashoshiashin,
cuz in having laid bare the scientific incredibility of
psychiatry, I'm thinking they'll wish they had maintained
the option of the criminal insanity defense.
THE MECHANICS OF FUNGAL-ANTIGEN-RELATED IMMUNE
SUPPRESSION- Brought to you as a summary of the available
science. Were there any responsible MDs who dared to
pass up the Yale Lyme Kool-Aid and do their homework, you would not
be reading it all here, first.
1) Tolerance Induced by the Lipopeptide Pam3Cys
[OspA] Is Due to Ablation of IL-1R-Associated Kinase-11
"Although a
single ligation of TLRs induces responses such as TNF production,
repeated ligation will lead to a loss of response, i.e., the
cells become tolerant." http://www.jimmunol.org/cgi/content/full/173/4/2736
2) "Borrelia burgdorferi-Induced Tolerance as a Model of Persistence via
Immunosuppression" -
"In summary, we characterized tolerance induced
by B. burgdorferi, describing a model of desensitization
which might mirror the immunosuppression recently attributed to the
persistence of Borrelia in immunocompetent hosts."
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12819085
3) Mycobacterium
tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human
Macrophage Class II MHC Antigen Processing1
http://www.jimmunol.org/cgi/content/full/173/4/2660
The Journal of Immunology, 2004, 173: 2660-2668. Copyright © 2004 by
The American Association of Immunologists
"Signaling
through TLR-2 by lipoproteins may represent a double-edged sword for host responses to chronic intracellular pathogens
such as M. tuberculosis. Short-term signaling through TLR-2
activates macrophages and initiates acute inflammation that
may help control initial infection. In contrast, prolonged
TLR-2 signaling in macrophages results in down-regulation of
certain critical immune functions, such as MHC-II Ag
processing. M. tuberculosis infects, survives, and
persists in macrophages. The ability of M. tuberculosis to
survive acute inflammation positions the bacilli to take
advantage, through secretion of lipoproteins such as LprG and
LpqH, of this
down-regulation of macrophage immune function."
4) Lipopolysaccharide Binding Protein Binds to Triacylated
and Diacylated Lipopeptides and Mediates Innate Immune Responses1
http://www.jimmunol.org/cgi/content/full/173/4/2683
"Lipoproteins and lipopeptides have been identified in a large
number
of microorganisms, the most prominent ones being mycobacteria, mycoplasms, and spirochetes. They have been found to exhibit
both a
strong innate inflammatory response in the host and an enduring
adaptive immune response in mammalian hosts (16).
The strong proinflammatory capacities of lipoproteins were first
described for outer surface proteins A and B of Borrelia burgdorferi,
which are also highly immunogenic (17)
and have lately been the basis for a Lyme disease vaccine development
(18).
These compounds exhibit an triacylated lipid anchor structure
comprising an N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl
(Pam3Cys) moiety at the N terminus (19),
a feature that was previously described for the Braun lipoprotein
from Escherichia coli (20).
Because the N-terminal Pam3Cys modification is essential for immunoactivation caused by lipoproteins of B. burgdorferi
as well as of another spirochete, Treponema pallidum (21),
subsequent studies investigating immune responses to spirochetes used
synthetic lipopeptides (22).
The Pam3Cys moiety was also reported to be present in
cytokine-inducing lipoproteins of Mycobacterium and Mycoplasma spp. (23,
24); thus,
it can be regarded as a highly conserved molecular motif among
different classes of bacteria. In Mycoplasma fermentans, the
presence of a macrophage stimulating lipopeptide, termed 2-kDa
macrophage-activating lipopeptide (MALP-2), was observed, being
stimulatory active at picomolar concentrations (25).
This compound, in contrast to the predominant lipopeptide structures
present in lipoproteins of E. coli, B. burgdorferi, and
mycobacteria, lacks the N-palmitoyl group, thus containing a
diacylated (Pam2Cys) lipid anchor structure at the N
terminus. Following studies revealed the presence of closely related
compounds in other Mycoplasma spp. (26).."
"Toll-like receptors (TLRs) 2 and 4 are
signal transducers for lipopolysaccharide, the major proinflammatory
constituent in the outer membrane of Gram-negative bacteria. We
observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi,
Treponema pallidum, and Mycoplasma fermentans
activated cells heterologously expressing TLR2 but not those
expressing TLR1 or TLR4. These TLR2-expressing cells were also
stimulated by living motile B. burgdorferi, suggesting that TLR2
recognition of lipoproteins is relevant to natural Borrelia
infection. Importantly, a TLR2 antibody inhibited bacterial
lipoprotein/lipopeptide-induced tumor necrosis factor release
from human peripheral blood mononuclear cells, and TLR2-null
Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide
challenge. The data suggest a role for the native protein in
cellular activation by these ligands. In addition, TLR2-dependent
responses were seen using whole Mycobacterium avium and
Staphylococcus aureus, demonstrating that this receptor can
function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through
TLR2 and propose that this molecule is a central pattern recognition
receptor in host immune responses to microbial invasion."
http://www.jimmunol.org/cgi/content/full/173/4/2683
AUGUST, 2008:
Human immunodeficiency virus infection alters tumor necrosis factor
alpha production via Toll-like receptor-dependent pathways in alveolar
macrophages and U1 cells.
http://www.ncbi.nlm.nih.gov/pubmed/18524817?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Center for HIV/AIDS Care and Research, Boston
University School of Medicine, Boston, MA 02118-2393, USA. mnicol@bu.edu
Human immunodeficiency virus (HIV)-positive persons are
predisposed to pulmonary infections, even after receiving effective highly
active antiretroviral therapy. The reasons for this are unclear but may
involve changes in innate immune function. HIV type 1 infection of
macrophages impairs effector functions, including cytokine production. We
observed decreased constitutive tumor necrosis factor alpha (TNF-alpha)
concentrations and increased soluble tumor necrosis factor receptor type II
(sTNFRII) in bronchoalveolar lavage fluid samples from HIV-positive subjects
compared to healthy controls. Moreover, net proinflammatory TNF-alpha
activity, as measured by the TNF-alpha/sTNFRII ratio, decreased as
HIV-related disease progressed, as manifested by decreasing CD4 cell count
and increasing HIV RNA (viral load). Since TNF-alpha is an important
component of the innate immune system and is produced upon activation of
Toll-like receptor (TLR) pathways, we hypothesized that the mechanism
associated with deficient TNF-alpha production in the lung involved altered
TLR expression or a deficit in the TLR signaling cascade. We found decreased
Toll-like receptor 1 (TLR1) and TLR4 surface expression in HIV-infected U1
monocytic cells compared to the uninfected parental U937 cell line and
decreased TLR message in alveolar macrophages (AMs) from HIV-positive
subjects. In addition, stimulation with TLR1/2 ligand (Pam(3)Cys) or TLR4
ligand (lipopolysaccharide) resulted in decreased intracellular
phosphorylated extracellular signal-regulated kinase and subsequent
decreased transcription and expression of TNF-alpha in U1 cells compared to
U937 cells. AMs from HIV-positive subjects also showed decreased TNF-alpha
production in response to these TLR2 and TLR4 ligands. We postulate that HIV
infection alters expression of TLRs with subsequent changes in mitogen-activated
protein kinase signaling and cytokine production that ultimately leads to
deficiencies of innate immune responses that predispose HIV-positive
subjects to infection.
http://www.jimmunol.org/cgi/content/full/170/1/508
Prior exposure to LPS both in vitro and in vivo can lead to
desensitization of immune cells to subsequent challenge
with LPS, a phenomenon that has been referred to as
"endotoxin tolerance."
Induction of in vitro reprogramming by
Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages:
effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa
B signaling pathway components.
Department of Microbiology and Immunology,
University of Maryland, Baltimore, MD 21201, USA.
In this study, tolerance induction by
preexposure of murine macrophages to Toll-like receptor (TLR)2 and
TLR4 agonists was revisited, focusing on the major signaling
components associated with NF-kappaB activation. Pretreatment of
macrophages with a pure TLR4 agonist (protein-free Escherichia coli
(Ec) LPS) or with TLR2 agonists (Porphyromonas gingivalis LPS or
synthetic lipoprotein Pam3Cys) led to suppression of TNF-alpha
secretion, IL-1R-associated kinase-1, and IkappaB kinase (IKK)
kinase activities, c-jun N-terminal kinase, and extracellular
signal-regulated kinase phosphorylation, and to suppression of NF-kappaB
DNA binding and transactivation upon challenge with the same agonist
(TLR4 or TLR2 "homotolerance," respectively). Despite inhibited NF-kappaB
DNA binding, increased levels of nuclear NF-kappaB were detected in
agonist-pretreated macrophages. For all the intermediate signaling
elements, heterotolerance was weaker than TLR4 or TLR2 homotolerance
with the exception of IKK kinase activity. IKK kinase activity was
unperturbed in heterotolerance. TNF-alpha secretion was also
suppressed in P. gingivalis LPS-pretreated, Ec LPS-challenged cells,
but not vice versa, while Pam3Cys and Ec LPS did not induce a state
of cross-tolerance at the level of TNF-alpha. Experiments designed
to elucidate novel mechanisms of NF-kappaB inhibition in tolerized
cells revealed the potential contribution of IkappaBepsilon and
IkappaBxi inhibitory proteins and the necessity of TLR4 engagement
for induction of tolerance to Toll receptor-IL-1R domain-containing
adapter protein/MyD88-adapter-like-dependent gene expression.
Collectively, these data demonstrate that induction of homotolerance
affects a broader spectrum of signaling components than in
heterotolerance, with selective modulation of specific elements
within the NF-kappaB signaling pathway.
TUBERCULOSIS (FUNGAL) VACCINES
FAILURES:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10792376&dopt=Abstract
The 19-kD antigen and
protective immunity in a murine model of tuberculosis.
Yeremeev VV, Lyadova IV,
Nikonenko BV, Apt AS, Abou-Zeid C, Inwald J, Young DB.
"The
19-kD antigen is a cell wall-associated lipoprotein present in
Mycobacterium tuberculosis and in bacille Calmette-Guérin (BCG)
vaccine strains. Expression of the 19-kD antigen as a
recombinant protein in two saprophytic mycobacteria-M. vaccae
and M. smegmatis-resulted in abrogation of their ability to
confer protection against M. tuberculosis in a murine challenge
model, and in their ability to prime a DTH response to
cross-reactive mycobacterial antigens. Induction of an immune
response to the 19-kD antigen by an alternative approach of DNA
vaccination had no effect on subsequent M. tuberculosis
challenge. These results are consistent with a model in which
the presence of the 19-kD protein has a detrimental effect on
the efficacy of vaccination with live mycobacteria. Targeted
inactivation of genes encoding selected antigens represents a
potential route towards development of improved vaccine
candidates."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11179309&dopt=Abstract
Mycobacterium tuberculosis
19-kilodalton lipoprotein inhibits Mycobacterium smegmatis-induced
cytokine production by human macrophages in vitro.
Post FA, Manca C, Neyrolles O, Ryffel B, Young DB, Kaplan G.
Vaccination of mice with
Mycobacterium vaccae or M. smegmatis induces some protection
against M. tuberculosis challenge. The 19-kDa lipoprotein of M.
tuberculosis, expressed in M. vaccae or M. smegmatis (M.
smeg19kDa), abrogates this protective immunity. To investigate
the mechanism of this suppression of immunity, human
monocyte-derived macrophages (MDM) were infected with M.
smeg19kDa. Infection resulted in reduced production of tumor
necrosis factor alpha (TNF-alpha) (P < 0.01), interleukin-12
(IL-12) (P < 0.05), IL-6 (P < 0.05), and IL-10 (P < 0.05),
compared to infection with M. smegmatis vector (M. smegV).
Infection with M. smeg19kDa and with M. smegV had no
differential effect on expression of costimulatory molecules on
MDM, nor did it affect the proliferation of presensitized T
cells cocultured with infected MDM. When MDM were infected with
M. smegmatis expressing mutated forms of the 19-kDa lipoprotein,
including non-O-glycosylated (M. smeg19NOG), nonsecreted (M.
smeg19NS), and nonacylated (M. smeg19NA) variants, the reduced
production of TNF-alpha or IL-12 was not observed. When the
purified 19-kDa lipoprotein was added directly to cultures of
infected monocytes, there was little effect on either induction
of cytokine production or its inhibition. Thus, the
immunosuppressive effect is dependent on glycosylated and
acylated 19-kDa lipoprotein present in the phagosome containing
the mycobacterium. These results suggest that the diminished
protection against challenge with M. tuberculosis seen in mice
vaccinated with M. smegmatis expressing the 19-kDa lipoprotein
is the result of reduced TNF-alpha and IL-12 production,
possibly leading to reduced induction of T-cell activation."
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12761093
-
Infect Immun. 2003
Jun;71(6):3146-54.
Related Articles,
Links
-
The Mycobacterium tuberculosis recombinant
27-kilodalton lipoprotein induces a strong Th1-type immune
response deleterious to protection.
Hovav AH, Mullerad J, Davidovitch L, Fishman Y, Bigi F, Cataldi
A, Bercovier H.
Department of Clinical Microbiology, Faculty of Medicine, The
Hebrew University, Jerusalem, Israel.
Th1 immune response is essential in the protection against
mycobacterial intracellular pathogens. Lipoproteins trigger both
humoral and cellular immune responses and may be candidate
protective antigens. We studied in BALB/c mice the
immunogenicity and the protection offered by the recombinant
27-kDa Mycobacterium tuberculosis lipoprotein and the
corresponding DNA vaccine. Immunization with the 27-kDa antigen
resulted in high titers of immunoglobulin G1 (IgG1) and IgG2a
with a typical Th1 profile and a strong delayed hypersensitivity
response. A strong proliferation response was observed in
splenocytes, and significant nitric oxide production and gamma
interferon secretion but not interleukin 10 secretion were
measured. Based on these criteria, the 27-kDa antigen induced a
typical Th1-type immune response thought to be necessary for
protection. Surprisingly, in 27-kDa-vaccinated mice (protein or
DNA vaccines) challenged by M. tuberculosis H37Rv or BCG
strains, there was a significant increase in the numbers of
CFU in the spleen compared to that for control groups.
Furthermore, the protection provided by BCG or other
mycobacterial antigens was completely abolished once the 27-kDa
antigen was added to the vaccine preparations. This study
indicates that the 27-kDa antigen has an adverse effect on the
protection afforded by recognized vaccines. We are currently
studying how the 27-kDa antigen modulates the mouse immune
response.
============================
============================
This is a separate (incomplete)
topic that has to do with mechanisms of survivability of nerve cells
in a toxic environment:
Multitarget siRNA inhibition of
antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells.
Department of Urology, Technical
University of Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany.
doreen.kunze@uniklinikum-dresden.de
BACKGROUND: The knockdown of XIAP, BCL2 and
BCL-X(L) by siRNAs represents a promising treatment option for
bladder cancer (BCa) since the overexpression of antiapoptotic
genes is often associated with tumor progression and treatment
resistance. MATERIALS AND METHODS: EJ28 BCa cells were
transfected with siRNAs--separately and combined--followed by
analysis of target expression, viability, clonogenic survival,
apoptosis and cell cycle. Furthermore, a possible chemosensitization
by siRNA pretreatment was investigated. RESULTS: The siRNA-mediated
inhibition of these targets--either separately or combined--reduced
the targets' expression, reduced cell growth and sensitized cells to
a subsequent chemotherapy. CONCLUSION: Since tumor cells may bypass
the inhibition of a single gene by changing their expression
profile, e.g. switch from BCL2 to BCL-X(L), the combined knockdown
of multiple genes of the same pathway might be more effective in
killing cancer cells. The siRNAs used represent appropriate tools
for this aim since they reduced their targets' expression
significantly and long-lastingly.
Organisation of the pericentromeric region of
chromosome 15: at least four partial gene copies are amplified
in patients with a proximal duplication of 15q
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11897815
Autoimmunity; degenerate T cells and CNS disease in Borreliosis
CHILDHOOD IMMUNIZATIONS and what is known about immune
incompetence (not all kids should get all vaccines without prescreening)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=9639369[uid]
Measles, mumps, and rubella--vaccine use and strategies
for elimination of measles, rubella, and congenital rubella syndrome and control
of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP).
These revised recommendations of the Advisory Committee
on Immunization Practices (ACIP) on measles, mumps, and rubella prevention
supersede recommendations published in 1989 and 1990. This statement summarizes
the goals and current strategies for measles, rubella, and congenital rubella
syndrome (CRS) elimination and for mumps reduction in the United States. Changes
from previous recommendations include: Emphasis on the use of combined MMR
vaccine for most indications; A change in the recommended age for routine
vaccination to 12-15 months for the first dose of MMR, and to 4-6 years for the
second dose of MMR; A recommendation that all states take immediate steps to
implement a two dose MMR requirement for school entry and any additional
measures needed to ensure that all school-aged children are vaccinated with two
doses of MMR by 2001; A clarification of the role of serologic screening to
determine immunity; A change in the criteria for determining acceptable evidence
of rubella immunity; A recommendation that all persons who work in health-care
facilities have acceptable evidence of measles and rubella immunity; Changes in
the recommended interval between administration of immune globulin and measles
vaccination; and Updated information on adverse events and contraindications,
particularly for persons with severe HIV infection, persons with a history of
egg allergy or gelatin allergy, persons with a history of thrombocytopenia, and
persons receiving steroid therapy.
MEDLINE:
Smallpox vaccination and Post-Vaccinal Encephalitis
Encephalitis complicating smallpox vaccination.
Department of Neurology, Indiana University School
of Medicine, and Indiana University Hospital, Indianapolis, USA.
A smallpox vaccination program has been initiated.
The vaccine is a live virus that was used in the last century. Postvaccinal
encephalitis is a complication of this vaccine. The clinical presentation,
course, neuroimaging findings, and spinal fluid abnormalities are similar to
a disorder that physicians are familiar with, acute disseminated
encephalomyelitis. This complication can be prevented with the
administration of antivaccinia gamma globulin at the time of vaccination.
Antivaccinia gamma globulin is not efficacious once this complication
occurs. Intravenous methylprednisolone is the recommended therapy, although
intravenous immunoglobulin and plasmapheresis should be investigated in the
treatment of postvaccinal encephalitis.
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