Blowing the Whistle at the FDA, Jan 2001, exposing Dearborn and how OspA causes immunosuppression rather than, "was a vaccine."
 


01 Oct 2017

Home


File List, RICO

1988 Steere says Lyme is like a B cell leukemia

Assoc Blogs-n-Webs:
TruthCures.org
badlymeattitude.com/
immune2lies.com/
researchfraud.com/
may12.org
meadvocacy.org/
truthbetoldx81
lymecryme
CrymeDiseaseNorway
crymedisease
theothersideofthestretcher
rjspiritualityandtuth
LymeTruthSite

JC-LilnkedIn
KD-Linkedin.com
LD-LinkedIn
JC-academia.edu

KD-academia.edu

 


CDC "SPIDER"

Fungal Exosomes Inhibit Apoptosis

IDSA: "Vaccines serve the mfgs, not their victims"

RICO_filed_USDOJ

BlumenthalAntiTrust Lawsuit

Exosomes, Blebs

Spirochetal_Dementia


PDFs
CDC Admits Fraud, 2016
Dattwyler, 1988
Golightly, 1988
Dressler, 1994
BarbourFish, 1993
Dearborn, 1994
BarbourFishpdf.pdf
 

Pathogenic Fungi

Bush's warcrimes, Oct 2000

Trainer

170708

 

Bogus Report on the Supremes from a Harvard Law CFR-er 

▲ To which we say, "Bullsh*t, Sir.  We can figure it out.  The nation is the rebellion... against the likes of yourself."
 

Glenn Greenwald:
Why Is a US Army Brigade Being Assigned to the 'Homeland'?

Good news, Mr. Greenwald.  They've never once made a weapon that they did not deploy, either accidentally or on purpose.  Having failed to scare us with the 911 thermate ruse, having lost Iraq, having rapidly rescued Russia in response to their international criminal antics, having been unable to secure the Afghan-Caspian pipelines and minerals for Enron, the surge having failed to secure for Baghdad oil contracts and a commercial oil-banking zone (remember Wolfowitz was to have that position, World OilBank Viceroy of Baghdad), having failed to convince us Guantanamo was cool, John Rowland's TREA Custodial Democracy scheme having flopped (in bed, as usual), making hysterical noises about pandemic flu (only to have it revealed that it will be a swine flu if there is ever a natural flu pandemic, since a lesser mutation allows it to "take" to human tissue) didn't electrify our hysters,  Americans are simply going to shoot the treacherous cops and troops and troopers in the streets.  It's going to be Civil War II, on top of Great Depression, II, because people have no respect for "law enforcers" whatsoever.

They showed us plainly and clearly, that they really were pigs - groveling, petty, trash-wallowing low-lives - all along.
Watch this video:

Everyone in CT should study this video (Judge Kaplan, State Troopers = INSANE!!)   RAILROADED, crooked Corrupticops, prosecutors and "judges"...

Who could have any respect for that kind of trash, after Abu Ghraib and tasering babies?

It's gonna be great!
 

And read this: http://www.counterpunch.org/hudson09252008.html

▲There never was a better smack upside the Palinite Neanderthals' Fake-Christian heads, but ya know what it won't matter because not only do people delusionally worship the uppercrust system (who abuse them), they worship their groveling low-life existence and they watch plenty of shoot-em-up cops shows and they think they're all "it" and they are all it, and they will be all it and it's gonna be brutal and great.  The banksters (psychiatry) taught them all they know about "I-Love-MEEEee" and others-hate. "Clean Slate:"

The Future of the United States   Howard Storm (Clean Slate)

"If the United States continues to exploit the rest of the world by greedily consuming the world's resources, the United States will have God's blessing withdrawn. Your country will collapse economically which will result in civil chaos. Because of the greedy nature of the people, you will have people killing people for a cup of gasoline. The world will watch in horror as your country is obliterated by strife. The rest of the world will not intervene because they have been victims of your exploitation. They will welcome the annihilation of such selfish people."
http://www.near-death.com/experiences/storm03.html


7
"(P)To the degree that she glorified herself and (Q)lived sensuously, to the same degree give her torment and mourning; for she says in her heart, '(R)I SIT as A QUEEN AND I AM NOT A WIDOW, and will never see mourning.'

8"For this reason (S)in one day her plagues will come, pestilence and mourning and famine, and she will be (T)burned up with fire; for the Lord God who judges her (U)is strong.

 

And now back to the program:

Anthrax Dirty Bomb  ◄ Says Pfizer's Mike Dunne, "Pfizer does not make Trovan any more" because they "can't get the starting materials," unaware, is Mike Dunne (because he is not a chemist as head of the Pfizer Infectious Diseases Division! over on the New London, CT side of the Thames), that I am an actual chemist and would know that that statement is baloney.

I thought you would all find that humorous because of:
http://www3.niaid.nih.gov/topics/BiodefenseRelated/default.htm

Hilarious.  Google TrovaZit.

======================================================

http://www.youtube.com/watch?v=1OTM8Y3a5zQ  ◄ Bailout Funny

======================================================

 

Turn the Corner:  http://www.youtube.com/watch?v=XnRrdtusWdw  You can't turn the corner until you back up to where the crooks took a wrong turn and have been publishing garbage ever since.  And that wrong turn was Dearborn.  It's amazing that people like Joe Burrascano thinks he can devise new "check lists" and that's going to be scientific.  You have to understand the scientific fraud and you have to expose it so that it gets prosecuted for the crime that it is.

Yikes.  ILADS.org is hopeless.

==================================

Says Willy Burgdorfer, discoverer of the Lyme Relapsing Fever spirochete, in the movie, UNDER OUR SKIN (Under Our Skin trailer),


"After 30 years we have NOTHING"  (You have to see the movie because you just have to see the look of total disgust on his face.  It's great.)
 

It's actually worse than nothing.  The Lyme crooks inhibited discovery in all diseases, including HIV and cancer, by lying about "Lyme disease" and OspA or the LYMErix and ImmuLyme vaccines.

See more about these crimes in the white box below the pink (fairies) box below.

I'm gonna show ya
 


CHAPTER 15
, PLUM ISLAND SLYME (OspA or special fungal Pam3Cys) and IMMUNE-SUPPRESSION

TLR2 and HLA (antibody production) down-regulation and auto-kill caspase & TNF inhibition inhibition = Plum Island's fungal secret antigen treasures (stealth disablers).
 

CHAPTER 28, The HISTORY of relapsing fever   33 years of crime and incompetence brings us back to 1975...

Says CDC officer Alan Barbour:  "We treat spirochetal diseases with other spirochetal diseases to cause a fever because antibiotics don't work."

This seems like an amazing! choice of treatment for a disease that does not exist or is easily cured by antibiotics, and especially, for a disease that has no brain residua.

 

 

 

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=373079&blobtype=pdf 
By CDC Officer Alan Barbour, in 1986, The Biology of Borrelia Species:

"The propensity for borrelia to go to the brain of infected mammals suggests that the relationship between these spirochetes and neural tissues is not trivial.  Further study of this attraction and the interaction that follows may reveal the basis for the significant nerve and brain involvement in Lyme borreliosis"--
 

Oh.
 

More about the mechanisms of immune suppression below this pinko (cuz that's what fascist authoritarians are, pinko commie fairies with no dicks) box:

 

"NO" TO THE BAILOUT 
If we sink, the banksters are going down with us.

"Paris-based financial analyst Max Keiser on the US financial meltdown says, "For the average American, this is what they will experience. The price of food and oil are going to skyrocket due to hyperinflation. The only way they can possibly pay for all these bailouts is to inflate the money supply. This means hyperinflation in America like you had in Germany in the 1920s. This is what the average American will experience: destitution, poverty, social unrest due to flagrant bank mismanagement - and it could have been avoided. But unfortunately the banks in the USA are run by greedy, insane private marketers and this is the result.”
http://www.presstv.ir/detail.aspx?id=70490&sectionid=3510203

 

 http://www.youtube.com/watch?v=vFU8DM2NjCk
 License plate # 5-7543, in case anyone was wonder how duh DCF could possibly be so stupid, lame, lazy, evil, retarded and yet dare to complain about how tough their job is:

 

http://www.youtube.com/watch?v=ycI8tZrcaFk&feature=related  ◄Yet another one.

http://www.youtube.com/watch?v=lyI1hPdxNhU&feature=related ◄ And this one was caught taking a leak while hiding from work in a State park, LOL.

http://www.youtube.com/watch?v=s8qCXm9zewg&feature=related  ◄Yet another one.

http://www.youtube.com/watch?v=nxw956i2m3Y&feature=related ◄ And another one.  (This appears to be a police officer scoping these idiots out.)

That's 5 separate DCF cars, LOL, all snoozin or peeing in the State parks.

 

- - - -

If we are experiencing an epidemic of asthma (and autism, hint, hint) in children, and asthma represents one end of the immune response to inhaled fungal antigens (immune suppression like the Chronic Fatigue Syndrome being the other end of the spectrum), then let's suggest that some kids are immune suppressed without anyone knowing it.  Thus, all kids should be prescreened for immune status before being given any vaccination.

We know the CDC is full of crap, and that they have said that they are aware of the vaccines-associated autism outcomes, but, according to the CDC, this damage is "a calculated risk."

CDC does the calculating and they have calculated that your kids are worthless experimental lab animals, much in the same manner as Allen Steere treated Dr. Michael A. Schwartz.

 

The people can't get past the porkers.
 

 

So bizarre is this state, that I had to listen to a lecture by a staff member of State Representative James Amann's (D- Milford) whose name also happens to be Kathleen.  Amann's Kathleen tells me she is a chemist and that she knows all about the testing for "Lyme Disease."  That surprises me because she would not be a chemist working for James Amann if that were true.  Amann's Kathleen tells me she knows more about Lyme disease than I do because her mother had it and that her mother got better from it.  Usually people are criticized when making general exclamations about medical conditions on the basis of a relative's brief experience with it.  In fact, the likes of Amann's "chemist" are the very scary tards the Lyme criminals warn us about.

Amann's full time job is to be a fund-raiser for the Multiple Sclerosis Society of America.  He gets a percent of the money he raises.  Thus, he is so good at selling himself and his retarded bullshit, he not only became a politician, he became the Connecticut State Speaker of the House.  The unions elect the democrats because republicans have generally, in the past, been against big government and unionized screw-driver-turners.  The republicans in Connecticut keep a low profile except for when they want to create the emergencies of "bad parents and criminals" in order to defraud Uncle Sam over how much "bad" goes on in this state, in order to not raise CT State income taxes.  It's a simple formulary where anyone who is not rich or a State employee union member is fodder for this human hamburger processor.  The mere people have the same function they did in Machu Picchu.  The mere people are the materiél and maintenance of slaughter needed to keep the political gods and the union gods happy so it will rain dollars from China.      Chapter 22, CRYME DISEASE.

 

Everyone in CT should study this video (Judge Kaplan, State Troopers = INSANE!!)   RAILROADED, crooked Corrupticops, prosecutors and "judges"

 

Corrupticut- Home of the Chocolate Burger. 

We're a human hamburger processing state and Black is our favorite flavor.

The New World Order is designed to terrorize the common people- take it from us, in Corrupticut.  
 

Repressed Speech at Quinnipiac (LOL, Everyday Life in Corrupticut)


The cops and duh DCF brutalized this man's kids because he won a police brutality lawsuit against the State Troopers   The details of the case are here.


http://starkravingviking.blogspot.com/2006_03_01_archive.html

◄"Judge" Howard "Cockadoodle-do" -sayin, "El-Stupido" -sayin, Violin-playin - Scheinblum at the March 2006 Hartford, CT,  Judiciary Committee Hearing where Steve and I took this next videotape:  

 

Representative Bill Dyson interviews future Judge Randolf-  "It's a PERCEPTION problem."

Randolf, "I never saw a white kid from Wesleyan charged with possession with intent."

That's right.  Everyone who is not a union member or a wealthy person else is "BAD," but the crazy psycho cops and the crazy DCF are the only "GOOD" people- yet they commit the worst crimes and happen to all Party and Screw together.

 

WHEREUPON, I got a letter from the Capitol Police....

REP. HOVEY: Thank you, Mr. Chairman. Before you, I'm not sure what the protocol is, do you want to close the public hearing? I have a comment I want to make.

REP. LAWLOR: Oh, sure, I can close the public hearing. No problem, it's okay.

REP. HOVEY: Okay, I just wanted to say that I respect the, respectfully object to the delay in the votes on these judges because it's my understanding that the delay is due to one of the nominees specifically.

And, from my perspective, we've appointed and appraised judges who have had significant issues with demeanor.

They're arrogant, pretentious and even dishonest, and that we have recently approved a judge who knowingly put children back into harm's way instead of using their judicial latitude to protect these children.

And the particular individual that we had earlier today, I believe the terms willful neglect and this or that about their circumstance, personal circumstance.

And what I would say is, someone who sits on this Committee with a--

[Whereupon, the hearing was adjourned.]====

 

“Whereupon, the hearing was adjourned.”  ???   

======================================================

Connecticut has more children in jail than anyplace else on earth and 82% of them are Black or LatinoCorrupticourts "judge" Jonathan Kaplan says kids belong to the State, first, that parents have "no divine right" to their children, and that Irish people are bad because they don't like British colonial dictatorship (much like the early USA and present day Palestine, I remind).  "Judge" Howard Scheinblum called a Latino person "El Stupido," in court and denied him a public defender (illegal).  Other defendants are asked to climb on a table (in court) and crow like a rooster, in order to get a reduced sentence.  Illegal wiretapping and illegal consults with "judges" who have absolute zero experience in the Corrupticourts have long been a Corrupticourts tradition...

http://www.topix.net/forum/source/hartford-courant/T50TF72FSEC9OIUAA#lastPost

 

Blumenthal is the STATE's attorney, not the people's attorney...Re: Challenging Atty Gen Blumethal

http://www.starkravingviking.blogspot.com/  Steve (The Viking) is very pissed and rightfully so.

Clarification:  CT Attorney General Richard Blumenthal works for the criminal State employees (UConn, State Troopers, DCF, and DMHAS), who committed the Lyme and other infamous crimes.  So, Connecticut could be sued in a class action, but Blumenthal would have to defend the State in that class action,... but he can't since he sued the Lyme criminals.

LOL.  It's tough to figure out unless you're some creepo lying lawyer or psychiatrist, always looking for an angle or a way to screw people. 

(I'm a scientist.  I just give people the facts, because facts are intended to mean something; or are the gift of truth.  The fact that facts are intended to mean actual, well, things, is something lawyers and psychiatrists would never understand, since scientific facts are so different from the hardwiring of their dominant lying left brains.  In a word, lawyers and psychiatrists are Aspergery with a fairy twist.)
 

Think about it.  How many times were State of Connecticut employees, including the head of the DCF and a "forensic psychiatrist for the State" given the proof that Lyme was a crime?  'Instead of doing what they're paid to do, protect people- not just sick people, but all people- from such crime?  Think about how many State employees perjured themselves to protect Yale's perjuring, lying, malpractitioning pervert, James Phillips, from a malpractice lawsuit.  You know it is true since how the hell else would I have been falsely criminally charged with being a "dangerously intelligent" "chemist, like Ted Kascynski?"

Think about it:  What year did Yale's Durland Fish and Edward McSweegan conspire to defraud Uncle Sam on their work time, using their dot guv and Yale email and work time?  1995 was right after the definition of "Lyme Disease" had changed, in October, 1994, at Dearborn.


Jan 31, 2001, I gave this presentation to the FDA Vaccine Committee:  http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf  ◄ That was the entire Lyme Cryme in a Nutcase State shell.  Allen Steere changed his own former diagnostic standard from Lyme as a Relapsing Fever organism to Lyme as only a late arthritis in a knee- the disease with no fatigue and no brain signs.  So, the State of CT could be sued in a class action.

This is all very creepy and very evil, but very typical of Corrupticut.  None of the men have any balls here, and all the MDs would like to be famous Yale ass-kissers.  They don't care that Yale committed the biggest medical crime in human history, that affects people on nearly all the inhabited continents and negatively affected research in nearly all chronic and deadly diseases, including cancer.

If any MDs in Corrupticut cared about this cryme, they would say something about it.  Notice none of even the ILADS.org MDs in Corrupticut say anything publicly or to the USDOJ that Lyme is a RICO and scientific fraud cryme committed by Allen Steere in Europe and perpetrated in Corrupticut, mainly by Yale's Robert Schoen.

Alice Walker:
What Our Country Desperately Needs is a Leader Who Loves Us

Sorry, Ms. Walker, I hate to inform you that Corrupticut is also the most racist hateful, vain, incompetent, selfish and stupid state in the Union.  If we had any leaders that love Americans, well, this website would not exist.  And this is my third website.  The first one went up 8 years ago.

Love means "do;" take action.

 

=============================================================

 

I alleged long ago, since I am a chemist, that the blot smudging in LYMErix vaccinated people could be due to multiple antibodies being produced to the various globulated forms of LYMErix in a vial, since I knew it would be next to impossible to perfectly micellize the lipoprotein OspA such that single molecules of it would be injected into LYMErix victims.

And viola, whaddya know, the Korean chemists who blasted (Mass Spec) the AIDS gp120 and gp41 "glycolipids" agreed:

Here's another report saying the same thing:

http://www3.interscience.wiley.com/cgi-bin/fulltext/120763430/PDFSTART

  (◄like LYMErix and E. coli's "Lipid A")

"A major problem of investigating the interaction of lipoprotein with lymphocyte membrane was its tendency to form aggregates..."  LOL, resulting in the unreadable Western Blots or the blot-smudging in LYMErix vaccination, rendering Western-Blots unreadable, and thus the LYMErix results a TOTAL FRAUD.


 

Now, none of this stuff is in Pam Weintraub's Lyme book, because I hadn't published it yet.
 

Watch the animation:
http://www.youtube.com/watch?v=RO8MP3wMvqg
 

 

HIV vaccine with Pam3Cys or something a lot like LYMErix stuck on it:

 

 

 

 

◄ This is supposedly how OspA lies in borrelia. The lipid portion appears to be buried in the spirochete membrane.  I do not not know how the glyco-lipids of HIV lie (the protein portion appears to be scrambled into the lipid portion), or even if for certain they're Pam3Cys, although I have no information that they're not.  I only have information that OspA and Pam3Cys have the same linear chemistry structure (but this is no predictor of presentation; the DNA can be sequenced, in other words).

 

From:
https://www.aidsreagent.org/program_info.cfm

I'll be dipped if I can find a proper linear structure of this online.  I guess that's because they can't X-ray diffract the real structure with the lipids stuck to it.  Can't find it in the patents and I can't find it online in the journals (free journals).

http://www.google.com/search?hl=en&q=HIV+gp120+structure+cysteine+tripalmitoyl&btnG=Search


Pam3Cys as adjuvant (Rockefeller University, 1992): http://www.ncbi.nlm.nih.gov/pubmed/1478779  (this is included in the Plum Island chapter)

http://metab2mesh.ncibi.org/index.php?term=tripalmitoyl+cysteine&qtype=substance

 

PLEASE SEE MORE OF THIS DATA BELOW THE WHITE BOX

============================

THE FOLLOWING IS TO BE USED AS AN INDICTMENT AGAINST YALE'S ROBERT SCHOEN and HARVARD'S ALLEN STEERE FOR RESEARCH FRAUD AND RACKETEERING.   I am still working on this, summarizing all the outcomes of the fraud- the lying to the FDA about the outcomes of LYMErix and changing the diagnostic standard of Lyme, knowing full-well, the only reliable antibody was Bb specific band 41 or flagellin.


The rapists Kaiser-Permanente, Allen Steere at the "Academy of Insurance Medicine", Yale, SmithKline, AIG, Mortimer Zuckerman, Anthony J. Walton, Philip Morris, and the cowardly, do-nothing staff of the CDC, NIH and FDA who participated in "theft of honest services." 

Remember, now, The Lyme crymes is a False Claims Act case against Yale University. 

What we are going to find is that Yale, by not reporting the adverse events to LYMErix (or bothering with these patients at all),
missed the common link to all chronic, devastating and deadly illnesses: ALS, MS, cancer, CFIDS/FM, Leukemia, what was wrong with the HIV vaccines, etc...  and that link was OspA- Yale's vaccine.  OspA is a fungal (mycoplasmal) antigen that turns off the immune system through various mechanisms.  This allows common latent viruses of all kinds to become unlatent.  The latently infected cells do not autokill as they should when the common latent viruses start replicating (the normal mechanism of immunity), and the fungal Pam3Cys antigen OspA, turns off antibody production against similar antigens.

1) Yale never had a Lyme vaccine (it was not proven to prevent Lyme).
2) Yale claims the Dearborn method is Lyme, when they have a truly validated test that proves otherwise.
3) Yale's Robert Schoen never reported to the FDA that he could not read his Western Blots in LYMErix vaccinated people, so he lied to the FDA about the efficacy and safety of LYMErix, Yale's patented vaccine.
4) Schoen instructed MDs to blow-off LYMErix systemic disease (immune suppression) victims, but reveals the RICO method in the Munchausen's book (libel).  This publication by Schoen is the single most significant reason the crime should be charged against Yale; L2 Diagnostics and PolyGenomics.  Schoen knew LYMErix was never a vaccine, he knew Dearborn was bogus, and he worked with Dave Persing on the primary or central RICO patent, but never told anyone the reason OspA and B were left out of the standard at Dearborn.

Gary Wormser reporting the blunting of the immune response in OspA vaccinated animals:
http://www.ncbi.nlm.nih.gov/pubmed/10865170?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

"OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression."

 

Says Dave Persing, formerly with the Mayo Clinic, and owner of the central Imugen-Corixa-L2 Diagnostics RICO patent (This is a patent for a modified OspA vaccine-as-an-adjuvant, but they never told the FDA they knew there were problems with LYMErix.  The patent was applied for in May, 2001, when LYMErix was still on the market- but none of the evil murderous bastards said a word to the FDA about this):

"Accordingly, the methods of the invention provide a powerful and selective approach for modulating the innate immune response pathways in animals without giving rise to the toxicities often associated with the native bacterial components that normally stimulate those pathways."   http://patft.uspto.gov/6,800,613

 

5) Yale claims their is no such thing as congenital Lyme, while having performed autopsies or reported about several congenital Lyme deaths and abnormal infant outcomes.
6) Schoen is playing a DNA/RNA primers shell game.  The RICO patent Borrelia strain was identified with the proper RNA methods, but these correct primers have never been used to assess treatment outcomes.
7) They committed this crime with clear intent to cause harm, due to all the obvious slander, perjury, stalking, wiretapping, and harassment, and especially, the Munchausen's accusations.

From the August, 2005 complaint to HomeLame Stupidity Secretary Jerkoff:

14) The Lyme disease racketeering crime involved insurance companies’ denial of care for chronic Lyme, which was also masterminded by Allen Steere when he defrauded the public by stating that late chronic nervous system Lyme was “some psychiatric disorder,” and wrote the “bogus article,”  Overdiagnosis [sic] of Lyme disease.”  In this “bogus” (a word used by Yale’s Durland Fish in correspondence with the NIH’s Edward McSweegan) scientific report, Steere also used the bogus high-passage strain G39/40, to not find Lyme.  Not finding Lyme saves insurance companies a great deal of money, since the relapsing-remitting treatment for this relapsing borreliosis, Lyme disease, which results in a Multiple Sclerosis-like syndrome according to Allen Steere (1991 Rheumatology News) costs $12,000 a month, minimally, as is the wholesale cost of the drug (the discounted price, where the pharmacy makes no profit).  The spin is to say Lyme victims are just CRAZY and don’t have a real illness (Chronic Fatigue Syndrome and Fibromyalgia are considered psychosomatic illnesses).  However, the malpractice treatment of late nervous system Lyme, which is treatment with psychotropics, increases the dementia. This malpractice is even clearly against the American Psychiatric Associations’ Guidelines for the treatment of a delirium, since these guidelines clearly state  “Medications for psychiatric disorders can be both the cause of delirium and exacerbate or contribute to delirium from other causes.”
 

8) Yale continues this crime because of the criminal liabilities associated with admitting their testing fraud (leaving OspA and B out of the diagnostic standard by using bogus strains in Europe).  They still publish bogus articles, ie., Klempner, 2001, on the Standard-of-Care of Lyme, which is the basis for the 2001 and 2006 "Infectious Disease Society of America's" "guidelines" on a "disease" that Gary Wormser and Mark Klempner have revealed have generally no fatigue or delirium in 2005: a late Lyme arthritis in a knee.  By and large, the only people who test positive to the new, bogus, 1994, CDC, Dearborn, Michigan, hypersensitivity reaction "case definition" are the late Lyme arthritis people, as explained in the RICO complaint to the USDOJ in the summer of 2003.
http://www.journals.uchicago.edu/doi/pdf/10.1086/432733?cookieSet=1  Click here to read

 

Here is proof that Gary Wormser knows that the current (Dearborn IgG) testing for Lyme only detects 9 of 59 patients according to Steere's IgG criteria: (9/59) = 15% ??



Read carefully what Wormser says in this ▲report:
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=266355&blobtype=pdf

Wormser says he is assessing Steere's IgG recommendation for the CDC to adopt (Dearborn), and that it was  NO GOOD.  Yet it was adopted by the CDC anyway.  Who approved this standard, even though none of the labs agreed?   

For Wormser to report in the IDSA guidelines and in the movie, Under Our Skin, that one has to have a positive test for Lyme, means he has  published scientific fraud.  Similarly, CDC says their testing for Lyme is "valid," when it is hardly valid, if only 15 % cases of Lyme are identified by IgG.

You can see the link to the YouTube clip of UnderOurSkin where Wormser says a person needs to have a positive test or a rash in order to have Lyme, here:  http://www.actionlyme.org/MOMS_CAN_GIVE_LYME_TO_BABIES.htm
▲At the bottom of the page.

 

The ALS outcome of Lyme is clearly deadly, but the Western Blots of those Lyme-ALS victims would never have tested positive to the Steere/Dearborn-Lyme-is-only-a-reactive-arthritis-in-a-knee-Method.  Hence, these will be murder charges.

Lou Gehrig's disease is also linked to fungal infections (Mycoplasma and OspA), as is the case with chronic Lyme and the Multiple Sclerosis outcome: MEDLINE LINK.  These chronic illnesses, these New Great Imitator outcomes, seem to be the result of the immune suppression caused by the shed fungal antigens, like OspA.


9) Yale and UConn performed a pediatric trial with LYMErix - knowing it was never a vaccine - in Europe on Czech children, without informing the Czech's that there is no OspA from B31 in Europe.  This is technically known as "assault."   The pediatric LYMErix trial had no value other than to determine how badly the children would be damaged.
10)
The reason the RICO cabal caved was because in the movie, UnderOurSkin, shown in New York City on April 26, 2008,  Yale's Eugene Shapiro flat-out lied his face off about congenital Lyme.  This made Blumenthal's staff utterly FURIOUS.


AIG is a supporter of this RICO clique

Kaiser-Permanente is a founder of the ALDF.com RICO enterprise at New York Medical College, in Valhalla, New York.

The FDA formally disclaims their responsibility to look at the data BigPharma sends them, to see if the perps followed FDA's testing rules (to see if their products actually do what they claim, or in the case of LYMErix, the FDA did not check the validity of the Dearborn method).

Not one single MD group or association anywhere in America says a single word about this RICO testing crime, despite the CT Attorney General's office suing the bastards, and the agreement looks like the perps want to avoid criminal charges.


LOL.  It was over congenital Lyme.  (4+ cases reported by Yale, Steere and Willy Burgdorfer)

 

Not one single newspaper has covered the story of the Lyme testing fraud.  Not one single newspaper interviewed Allen Steere and asked him why he went to Europe with a bogus "high-passage" strain to invent the new Dearborn (CDC) diagnostic standard- the one Gary Wormser reported only detected 9/59 cases of Lyme.

Not one single newspaper interviewed anyone at the CDC and asked them about the meaning of their MHC-restricted antibodies claims in their 1992 patents with SmithKline in Europe.

Not one single medical journal or medical society in the entire USA or Europe ever had a scientific team look into our claims that changing the diagnostic standard for Lyme (to make it only a late Lyme arthritis in a knee) was scientific fraud, despite the Blumenthal lawsuit.

Not one single newspaper or medical society looked into and reported that Yale missed all the immune suppression outcomes caused by a fungal vaccine (OspA or LYMErix) and the auto-vaccination or auto-tolerization process of spirochetal blebbing, that resulted in all the New Great Imitator outcomes or the immune dysregulation/suppression outcomes (they are the same), or considered what this crime's effect might be on discovery in other chronic illnesses, including cancer and HIV.

http://www.jimmunol.org/cgi/content/full/170/1/508

Prior exposure to LPS both in vitro and in vivo can lead to desensitization of immune cells to subsequent challenge with LPS, a phenomenon that has been referred to as "endotoxin tolerance."

(There is more of this kind of data below this white box; the issue for chronic Lyme is tolerance to fungal infections of the blood, like mycoplasma and Candida albicans, or tolerance that leads to the phenomenon of common virally infected cells becoming un-latent, and then not auto-killing, eg, Epstein-Barr, cytomegalovirus, HHV-6 etc, which most people with chronic neurologic Lyme have.)

 

You all see this data nowhere else in the world, correct?

◄"On occasion, these atypical-appearing large lymphocytes have been misinterpreted in biopsy by several laboratories as cells of a malignant lymphoma or leukemia.  Bb antigens, then, may stimulate growth of immature lymphocytic suibsets in some target organs, as well as in the cerebrospinal fluid (Szyfelbein and Ross 1988).  Usual bacterial infections do not produce such lymphocytic infiltrates in tissue.  These immunoblastoid cells in Bb infections at times resemble those found in Epstein-Barr virus infections.  Does Bb reactivate latent virus infections in tissues?  Do some tick inocula harbor simultaneous infectious agents (ixodid ticks can harbor Rickettsiae, Babesia microti, and Ehrlichia bacteria, in addition to Bb), producing multi-agent infections in some hosts?  Further studies can clarify these issues by mans of tissue-based molecular probe analysis." - 
 Paul Duray, NCI, NIH, Ft. Detrick, at the 1992 Cold Spring Harbor Crooks' Conference, published in Steve Schutzer's Lyme Disease: Molecular and Immunologic Approaches.
http://www.amazon.com/Lyme-Disease-Immunologic-Approaches-Communications/dp/0879693770/ref=sr_1_2?ie=UTF8&s=books&qid=1214848669&sr=1-2



I think it is so frickin funny that not a single MD in America has any balls or brains.  Not even when you put a whole bunch of them together.  Not even as a group do they have a ball or a brain cell.

THAT'S America.

Check it out:
http://www.ncbi.nlm.nih.gov/pubmed/15385250?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 
 J Neurovirol. 2004 Oct;10(5):278-83.Click here to read Links
 

Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein.

Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway. trygveho@labmed.uio.no

Epstein-Barr virus-specific CD4+ T cells could be involved in the pathogenesis of multiple sclerosis, provided they can gain entry to the intrathecal compartment. The authors have previously demonstrated that cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells. They now report that CD4+ T cells specific for the Epstein-Barr virus DNA polymerase peptide EBV 627-641 were present in the cerebrospinal fluid from one of two multiple sclerosis patients, and that a high proportion of these CD4+ T cells cross-recognized an immunodominant myelin basic protein peptide, MBP 85-99. In the observed patient, the proportion of EBV 627-641-specific CD4+ T cells seemed to exceed 1/10,000 in cerebrospinal fluid, compared to approximately 1/100,000 in blood. These findings prove that Epstein-Barr-virus specific CD4+ T cells can gain access to the intrathecal compartment, and suggest that Epstein-Barr virus-specific CD4+ T cells could target myelin basic protein in the central nervous system.
 

 
Lyme and Multiple Sclerosis? 

Who is Roland Martin?

Multiple Sclerosis, I note, is not an autoimmune arthritis in a knee.

Chronic Lyme and LYMErix Disease are all the New Great Imitator immune suppression outcomes that are associated with Pam3Cys or OspA.  That's why LYMErix came off the market.  It wasn't because of poor sales, but because it gave people immune suppression outcomes, just like the ones into which chronic Lyme progresses (ALS, MS, Chronic Fatigue, MS, blood cancers, multiple myeloma, Fibromyalgia...). 

The immune suppression caused by chronic Lyme (Relapsing Fever with a mycoplasmal twist) result in the activation of latent viruses of all kinds, like Epstein-Barr, leading to the likes of cancers and Multiple Sclerosis, since viruses are well-known to be associated with the development of cancers.

That's why Ft. Detrick and the National Cancer Institute are basically interrelated, which was how Paul Duray came into the picture, because he works for both.  Duray actually worked with Steven Hatfill.


CDC Officer and ALDF Bioracketeer Alan Barbour explaining:  "Immune System Overhwhelmed," US Patent 6,719,983-

"2.1 Methods of Treatment

"An important aspect of the invention is the recognition that Borrelia VMP-like sequences recombine at the vls site, with the result that antigenic variation is virtually limitless. Multiclonal populations therefore can exist in an infected patient so that immunological defenses are severely tested if not totally overwhelmed."

- - - - - -

"He finds that during the early stages of infection, B. burgdorferi avoids immune detection by decreasing its expression of surface proteins or cloaking its expressed surface proteins under a layer of slime. "It's using some sort of stealth-bomber-type mechanism," he says. Or, using another diversionary tactic called blebbing, the spirochete can pinch off bits of its membrane in order to release its surface proteins. Explains Barbour: "It's like a bacterial Star Wars defense program," in which released surface proteins might intercept incoming host antibodies keeping the spirochetes safe from immunological attack."
--
1996, The Crooks.

 


 

Mycoplasma adhering to, embedding into erythrocytes ◄ Go here for more excellent graphics    (Click on image to view larger version)

http://iai.asm.org/cgi/content/full/76/1/71/F1

Figure 1

FIG. 1. Scanning electron micrographs of sheep (A) and chicken (B) erythrocytes after in vitro infection with a clonal derivative of M. gallisepticum strain Rlow. The arrows indicate mycoplasmas or imprints of mycoplasmas appearing to sink into the erythrocyte surface.


I would say mycoplasmal infections distort the shape of erythrocytes, no?  Anyone with Chronic Fibrofemzalgilyme will tell you that we have normal hemoglobin but we're so tired.  So how could our blood cells possibly be getting adequate oxygen to our cells??

Since we know we're not making up our symptoms, we knew there would be discovered scientifically valid explanations or at least scientifically scientific and not sooth-sayin crystal-ballific explanations.

Right.  And those are just erythrocytes.  I'm thinking IDSA is going to be somewhat regretful for having deployed the Quija-Boarders, the American Psychiatrogenic Ashoshiashin, cuz in having laid bare the scientific incredibility of psychiatry, I'm thinking they'll wish they had maintained the option of the criminal insanity defense.


THE MECHANICS OF FUNGAL-ANTIGEN-RELATED IMMUNE SUPPRESSION-  Brought to you as a summary of the available science.   Were there any responsible MDs who dared to pass up the Yale Lyme Kool-Aid and do their homework, you would not be reading it all here, first.

 

1) Tolerance Induced by the Lipopeptide Pam3Cys [OspA] Is Due to Ablation of IL-1R-Associated Kinase-11  

"Although a single ligation of TLRs induces responses such as TNF production, repeated ligation will lead to a loss of response, i.e., the cells become tolerant."   http://www.jimmunol.org/cgi/content/full/173/4/2736

 

2) "Borrelia burgdorferi-Induced Tolerance as a Model of Persistence via Immunosuppression" - 

"In summary, we characterized tolerance induced by B. burgdorferi, describing a model of desensitization which might mirror the immunosuppression recently attributed to the persistence of Borrelia in immunocompetent hosts."
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12819085

 

3) Mycobacterium tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing1
 http://www.jimmunol.org/cgi/content/full/173/4/2660    

The Journal of Immunology, 2004, 173: 2660-2668.
Copyright © 2004 by The American Association of Immunologists
 

 "Signaling through TLR-2 by lipoproteins may represent a double-edged sword for host responses to chronic intracellular pathogens such as M. tuberculosis. Short-term signaling through TLR-2 activates macrophages and initiates acute inflammation that may help control initial infection. In contrast, prolonged TLR-2 signaling in macrophages results in down-regulation of certain critical immune functions, such as MHC-II Ag processing. M. tuberculosis infects, survives, and persists in macrophages. The ability of M. tuberculosis to survive acute inflammation positions the bacilli to take advantage, through secretion of lipoproteins such as LprG and LpqH, of this down-regulation of macrophage immune function." 
 

4) Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses1
http://www.jimmunol.org/cgi/content/full/173/4/2683
 

"Lipoproteins and lipopeptides have been identified in a large number of microorganisms, the most prominent ones being mycobacteria, mycoplasms, and spirochetes. They have been found to exhibit both a strong innate inflammatory response in the host and an enduring adaptive immune response in mammalian hosts (16). The strong proinflammatory capacities of lipoproteins were first described for outer surface proteins A and B of Borrelia burgdorferi, which are also highly immunogenic (17) and have lately been the basis for a Lyme disease vaccine development (18). These compounds exhibit an triacylated lipid anchor structure comprising an N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl (Pam3Cys) moiety at the N terminus (19), a feature that was previously described for the Braun lipoprotein from Escherichia coli (20). Because the N-terminal Pam3Cys modification is essential for immunoactivation caused by lipoproteins of B. burgdorferi as well as of another spirochete, Treponema pallidum (21), subsequent studies investigating immune responses to spirochetes used synthetic lipopeptides (22). The Pam3Cys moiety was also reported to be present in cytokine-inducing lipoproteins of Mycobacterium and Mycoplasma spp. (23, 24); thus, it can be regarded as a highly conserved molecular motif among different classes of bacteria. In Mycoplasma fermentans, the presence of a macrophage stimulating lipopeptide, termed 2-kDa macrophage-activating lipopeptide (MALP-2), was observed, being stimulatory active at picomolar concentrations (25). This compound, in contrast to the predominant lipopeptide structures present in lipoproteins of E. coli, B. burgdorferi, and mycobacteria, lacks the N-palmitoyl group, thus containing a diacylated (Pam2Cys) lipid anchor structure at the N terminus. Following studies revealed the presence of closely related compounds in other Mycoplasma spp. (26).."   
 

"Toll-like receptors (TLRs) 2 and 4 are signal transducers for lipopolysaccharide, the major proinflammatory constituent in the outer membrane of Gram-negative bacteria. We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or TLR4. These TLR2-expressing cells were also stimulated by living motile B. burgdorferi, suggesting that TLR2 recognition of lipoproteins is relevant to natural Borrelia infection. Importantly, a TLR2 antibody inhibited bacterial lipoprotein/lipopeptide-induced tumor necrosis factor release from human peripheral blood mononuclear cells, and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge. The data suggest a role for the native protein in cellular activation by these ligands. In addition, TLR2-dependent responses were seen using whole Mycobacterium avium and Staphylococcus aureus, demonstrating that this receptor can function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through TLR2 and propose that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion."   http://www.jimmunol.org/cgi/content/full/173/4/2683

 

AUGUST, 2008:

Human immunodeficiency virus infection alters tumor necrosis factor alpha production via Toll-like receptor-dependent pathways in alveolar macrophages and U1 cells.
http://www.ncbi.nlm.nih.gov/pubmed/18524817?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Center for HIV/AIDS Care and Research, Boston University School of Medicine, Boston, MA 02118-2393, USA. mnicol@bu.edu

Human immunodeficiency virus (HIV)-positive persons are predisposed to pulmonary infections, even after receiving effective highly active antiretroviral therapy. The reasons for this are unclear but may involve changes in innate immune function. HIV type 1 infection of macrophages impairs effector functions, including cytokine production. We observed decreased constitutive tumor necrosis factor alpha (TNF-alpha) concentrations and increased soluble tumor necrosis factor receptor type II (sTNFRII) in bronchoalveolar lavage fluid samples from HIV-positive subjects compared to healthy controls. Moreover, net proinflammatory TNF-alpha activity, as measured by the TNF-alpha/sTNFRII ratio, decreased as HIV-related disease progressed, as manifested by decreasing CD4 cell count and increasing HIV RNA (viral load). Since TNF-alpha is an important component of the innate immune system and is produced upon activation of Toll-like receptor (TLR) pathways, we hypothesized that the mechanism associated with deficient TNF-alpha production in the lung involved altered TLR expression or a deficit in the TLR signaling cascade. We found decreased Toll-like receptor 1 (TLR1) and TLR4 surface expression in HIV-infected U1 monocytic cells compared to the uninfected parental U937 cell line and decreased TLR message in alveolar macrophages (AMs) from HIV-positive subjects. In addition, stimulation with TLR1/2 ligand (Pam(3)Cys) or TLR4 ligand (lipopolysaccharide) resulted in decreased intracellular phosphorylated extracellular signal-regulated kinase and subsequent decreased transcription and expression of TNF-alpha in U1 cells compared to U937 cells. AMs from HIV-positive subjects also showed decreased TNF-alpha production in response to these TLR2 and TLR4 ligands. We postulate that HIV infection alters expression of TLRs with subsequent changes in mitogen-activated protein kinase signaling and cytokine production that ultimately leads to deficiencies of innate immune responses that predispose HIV-positive subjects to infection.

 

http://www.jimmunol.org/cgi/content/full/170/1/508

Prior exposure to LPS both in vitro and in vivo can lead to desensitization of immune cells to subsequent challenge with LPS, a phenomenon that has been referred to as "endotoxin tolerance."

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.

In this study, tolerance induction by preexposure of murine macrophages to Toll-like receptor (TLR)2 and TLR4 agonists was revisited, focusing on the major signaling components associated with NF-kappaB activation. Pretreatment of macrophages with a pure TLR4 agonist (protein-free Escherichia coli (Ec) LPS) or with TLR2 agonists (Porphyromonas gingivalis LPS or synthetic lipoprotein Pam3Cys) led to suppression of TNF-alpha secretion, IL-1R-associated kinase-1, and IkappaB kinase (IKK) kinase activities, c-jun N-terminal kinase, and extracellular signal-regulated kinase phosphorylation, and to suppression of NF-kappaB DNA binding and transactivation upon challenge with the same agonist (TLR4 or TLR2 "homotolerance," respectively). Despite inhibited NF-kappaB DNA binding, increased levels of nuclear NF-kappaB were detected in agonist-pretreated macrophages. For all the intermediate signaling elements, heterotolerance was weaker than TLR4 or TLR2 homotolerance with the exception of IKK kinase activity. IKK kinase activity was unperturbed in heterotolerance. TNF-alpha secretion was also suppressed in P. gingivalis LPS-pretreated, Ec LPS-challenged cells, but not vice versa, while Pam3Cys and Ec LPS did not induce a state of cross-tolerance at the level of TNF-alpha. Experiments designed to elucidate novel mechanisms of NF-kappaB inhibition in tolerized cells revealed the potential contribution of IkappaBepsilon and IkappaBxi inhibitory proteins and the necessity of TLR4 engagement for induction of tolerance to Toll receptor-IL-1R domain-containing adapter protein/MyD88-adapter-like-dependent gene expression. Collectively, these data demonstrate that induction of homotolerance affects a broader spectrum of signaling components than in heterotolerance, with selective modulation of specific elements within the NF-kappaB signaling pathway.

 

TUBERCULOSIS (FUNGAL) VACCINES FAILURES:

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10792376&dopt=Abstract
The 19-kD antigen and protective immunity in a murine model of tuberculosis. 
Yeremeev VV, Lyadova IV, Nikonenko BV, Apt AS, Abou-Zeid C, Inwald J, Young DB.

"The 19-kD antigen is a cell wall-associated lipoprotein present in Mycobacterium tuberculosis and in bacille Calmette-Guérin (BCG) vaccine strains. Expression of the 19-kD antigen as a recombinant protein in two saprophytic mycobacteria-M. vaccae and M. smegmatis-resulted in abrogation of their ability to confer protection against M. tuberculosis in a murine challenge model, and in their ability to prime a DTH response to cross-reactive mycobacterial antigens. Induction of an immune response to the 19-kD antigen by an alternative approach of DNA vaccination had no effect on subsequent M. tuberculosis challenge. These results are consistent with a model in which the presence of the 19-kD protein has a detrimental effect on the efficacy of vaccination with live mycobacteria. Targeted inactivation of genes encoding selected antigens represents a potential route towards development of improved vaccine candidates."

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11179309&dopt=Abstract

Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits Mycobacterium smegmatis-induced cytokine production by human macrophages in vitro.

Post FA, Manca C, Neyrolles O, Ryffel B, Young DB, Kaplan G.
 

Vaccination of mice with Mycobacterium vaccae or M. smegmatis induces some protection against M. tuberculosis challenge. The 19-kDa lipoprotein of M. tuberculosis, expressed in M. vaccae or M. smegmatis (M. smeg19kDa), abrogates this protective immunity. To investigate the mechanism of this suppression of immunity, human monocyte-derived macrophages (MDM) were infected with M. smeg19kDa. Infection resulted in reduced production of tumor necrosis factor alpha (TNF-alpha) (P < 0.01), interleukin-12 (IL-12) (P < 0.05), IL-6 (P < 0.05), and IL-10 (P < 0.05), compared to infection with M. smegmatis vector (M. smegV). Infection with M. smeg19kDa and with M. smegV had no differential effect on expression of costimulatory molecules on MDM, nor did it affect the proliferation of presensitized T cells cocultured with infected MDM. When MDM were infected with M. smegmatis expressing mutated forms of the 19-kDa lipoprotein, including non-O-glycosylated (M. smeg19NOG), nonsecreted (M. smeg19NS), and nonacylated (M. smeg19NA) variants, the reduced production of TNF-alpha or IL-12 was not observed. When the purified 19-kDa lipoprotein was added directly to cultures of infected monocytes, there was little effect on either induction of cytokine production or its inhibition. Thus, the immunosuppressive effect is dependent on glycosylated and acylated 19-kDa lipoprotein present in the phagosome containing the mycobacterium. These results suggest that the diminished protection against challenge with M. tuberculosis seen in mice vaccinated with M. smegmatis expressing the 19-kDa lipoprotein is the result of reduced TNF-alpha and IL-12 production, possibly leading to reduced induction of T-cell activation."

 

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12761093

  Infect Immun. 2003 Jun;71(6):3146-54. Related Articles, Links
  
The Mycobacterium tuberculosis recombinant 27-kilodalton lipoprotein induces a strong Th1-type immune response deleterious to protection.

Hovav AH, Mullerad J, Davidovitch L, Fishman Y, Bigi F, Cataldi A, Bercovier H.

Department of Clinical Microbiology, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.

Th1 immune response is essential in the protection against mycobacterial intracellular pathogens. Lipoproteins trigger both humoral and cellular immune responses and may be candidate protective antigens. We studied in BALB/c mice the immunogenicity and the protection offered by the recombinant 27-kDa Mycobacterium tuberculosis lipoprotein and the corresponding DNA vaccine. Immunization with the 27-kDa antigen resulted in high titers of immunoglobulin G1 (IgG1) and IgG2a with a typical Th1 profile and a strong delayed hypersensitivity response. A strong proliferation response was observed in splenocytes, and significant nitric oxide production and gamma interferon secretion but not interleukin 10 secretion were measured. Based on these criteria, the 27-kDa antigen induced a typical Th1-type immune response thought to be necessary for protection. Surprisingly, in 27-kDa-vaccinated mice (protein or DNA vaccines) challenged by M. tuberculosis H37Rv or BCG strains, there was a significant increase in the numbers of CFU in the spleen compared to that for control groups. Furthermore, the protection provided by BCG or other mycobacterial antigens was completely abolished once the 27-kDa antigen was added to the vaccine preparations. This study indicates that the 27-kDa antigen has an adverse effect on the protection afforded by recognized vaccines. We are currently studying how the 27-kDa antigen modulates the mouse immune response.

 

============================

============================

This is a separate (incomplete) topic that has to do with mechanisms of survivability of nerve cells in a toxic environment:

 

Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells.

Department of Urology, Technical University of Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. doreen.kunze@uniklinikum-dresden.de

BACKGROUND: The knockdown of XIAP, BCL2 and BCL-X(L) by siRNAs represents a promising treatment option for bladder cancer (BCa) since the overexpression of antiapoptotic genes is often associated with tumor progression and treatment resistance. MATERIALS AND METHODS: EJ28 BCa cells were transfected with siRNAs--separately and combined--followed by analysis of target expression, viability, clonogenic survival, apoptosis and cell cycle. Furthermore, a possible chemosensitization by siRNA pretreatment was investigated. RESULTS: The siRNA-mediated inhibition of these targets--either separately or combined--reduced the targets' expression, reduced cell growth and sensitized cells to a subsequent chemotherapy. CONCLUSION: Since tumor cells may bypass the inhibition of a single gene by changing their expression profile, e.g. switch from BCL2 to BCL-X(L), the combined knockdown of multiple genes of the same pathway might be more effective in killing cancer cells. The siRNAs used represent appropriate tools for this aim since they reduced their targets' expression significantly and long-lastingly.

 

Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in patients with a proximal duplication of 15q
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11897815
 

 

Autoimmunity; degenerate T cells and CNS disease in Borreliosis

 

 

CHILDHOOD IMMUNIZATIONS and what is known about immune incompetence (not all kids should get all vaccines without prescreening)

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=9639369[uid]

 
MMWR Recomm Rep. 1998 May 22;47(RR-8):1-57.Click here to read Links
 

Measles, mumps, and rubella--vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP).

These revised recommendations of the Advisory Committee on Immunization Practices (ACIP) on measles, mumps, and rubella prevention supersede recommendations published in 1989 and 1990. This statement summarizes the goals and current strategies for measles, rubella, and congenital rubella syndrome (CRS) elimination and for mumps reduction in the United States. Changes from previous recommendations include: Emphasis on the use of combined MMR vaccine for most indications; A change in the recommended age for routine vaccination to 12-15 months for the first dose of MMR, and to 4-6 years for the second dose of MMR; A recommendation that all states take immediate steps to implement a two dose MMR requirement for school entry and any additional measures needed to ensure that all school-aged children are vaccinated with two doses of MMR by 2001; A clarification of the role of serologic screening to determine immunity; A change in the criteria for determining acceptable evidence of rubella immunity; A recommendation that all persons who work in health-care facilities have acceptable evidence of measles and rubella immunity; Changes in the recommended interval between administration of immune globulin and measles vaccination; and Updated information on adverse events and contraindications, particularly for persons with severe HIV infection, persons with a history of egg allergy or gelatin allergy, persons with a history of thrombocytopenia, and persons receiving steroid therapy.

 

MEDLINE: Smallpox vaccination and Post-Vaccinal Encephalitis 

Arch Neurol. 2003 Jul;60(7):925-8.Click here to read Links
 

Encephalitis complicating smallpox vaccination.

Department of Neurology, Indiana University School of Medicine, and Indiana University Hospital, Indianapolis, USA.

A smallpox vaccination program has been initiated. The vaccine is a live virus that was used in the last century. Postvaccinal encephalitis is a complication of this vaccine. The clinical presentation, course, neuroimaging findings, and spinal fluid abnormalities are similar to a disorder that physicians are familiar with, acute disseminated encephalomyelitis. This complication can be prevented with the administration of antivaccinia gamma globulin at the time of vaccination. Antivaccinia gamma globulin is not efficacious once this complication occurs. Intravenous methylprednisolone is the recommended therapy, although intravenous immunoglobulin and plasmapheresis should be investigated in the treatment of postvaccinal encephalitis.