24 May 2012 

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Natural Remedies
 

CDC Greed (won't answer the FOIA)

ELISA = arbitrary cutoff.

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Overview

TUSKEGEE - By Jerry Leonard

1998, CIA Oilmen & Israelis plan to overthrow Saddam for the oil.

Bush/Gore  Oil/War-(Oct,2000)  

Bush's own explainer (Oct 2000) re: Iraq Oil

ALL BROOKHAVEN CRISP GRANTS BELOW

BROOKHAVEN and BIOWEAPONS

Grant Number:   1U01AI056480-01
PI Name:        DUNN, JOHN J.
PI Email:       j...@bnl.gov
PI Title:       SENIOR SCIENTIST
Project Title:  Rapid Detection and Identification of Zoonotic Pathogens
 

Abstract: DESCRIPTION (provided by applicant): Zoonotic pathogens
including those transmitted by insect vectors are some of the most
deadly of all infectious diseases known to mankind. In the past, wars
and natural disasters were the main catalysts that promoted epidemics
of these ancient afflictions, which are normally transmitted by fleas,
lice and ticks. Many of these diseases remain endemic in various
regions of the world and therefore pose serious threats to U.S. armed
forces troops and civilians who might enter endemic disease zones. A
number of these agents have been further weaponized and are widely
recognized as being the most significant biothreat agents. Study of
disease agents and development of rapid means for their detection take
on added importance in light of the use of anthrax for a bioterror
attack on the U.S.A. The aim of this proposal is to modify a novel
DNA-based methodology we have developed for profiling genomic DNAs to
permit rapid, cultivation-free differential detection and
identification of biothreat infectious agents in their natural
environments, including intermediate infected hosts, and clinical
specimens from humans or infected animals. We plan to use Borrelia
burgdorferi, the arthropod-borne etiologic agent of Lyme disease and
Yersinia pestis, the etiologic agent of plague, as our principle test
agents to work through the systems. We will begin with B. burgdorferi
since although it has a complicated life-cycle involving both
arthropod and animal intermediates, it is easy to grow and we have
extensive experience in working with it in different complex
environments including ticks, rodents and human samples. Thus it gives
us the opportunity of detecting this pathogen in a variety of complex
environments. We also have significant experience with characterizing
and identifying subtle changes in the genome of Y. pestis utilizing
genomic signature tags. We will use these methods as the foundation of
new, high-throughput sequence-based systems to detect zoonotic and/or
vector-borne biothreat agents such as Yersinia pestis, Francisella
tularensis, Rickettsia ricketsii and other human pathogens such as
Ehrlichia and Babesia species. This technology can ultimately be
adapted as a sensitive method to detect specific DNA signature
sequences from both known and unknown pathogens in a wide variety of
complex environments and since it is PCR-based it has the advantage
that only minimal quantities of starting material are needed for
analysis.
 

Thesaurus Terms:
biohazard detection, communicable disease diagnosis, diagnosis design /evaluation, genetic technique, high throughput technology, method development Borrelia, Yersinia pestis, cooperative study, informatics, molecular biology information system, nucleic acid sequence biotechnology, bioterrorism /chemical warfare, clinical research, human tissue, laboratory mouse, microarray technology
 

Institution:    BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
        BROOKHAVEN NATIONAL LAB
        UPTON, NY 11973
Fiscal Year:    2003
Department:    
Project Start:  15-SEP-2003
Project End:    29-FEB-2008
ICD:    NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG:    ZAI1

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The Department of Energy's National Synchrotron Light Source at Brookhaven National Laboratory helped researchers discover new information about the bacterium that causes Lyme disease. Their work may lead to an effective vaccine and new treatment protocols.     MORE HERE

"It's the perfect stealth bacteria," says one frustrated physician. He's talking about Borrelia burgdorferi, the bacterium that causes Lyme disease. This illness, which is often mistaken for diseases ranging from multiple sclerosis to Lupus, can inflict excruciating headaches and muscle pain, affect the brain and nervous system, attack major organs, and inflame joints. Although there have been more than 100,000 reports of the tick-borne Lyme disease in the U.S. since 1982, researchers are still struggling to create vaccines and treatments that are effective against B. burgdorferi.

New findings may explain vaccine failure, suggest treatment approaches Investigators are particularly pleased with two recent discoveries made using the Department of Energy's National Synchronous Light Source (NSLS) at Brookhaven National Laboratory. The uniquely refined images they were able to create demonstrated the bacterium changes its outer surface protein according to its host, and that different strains of the bacterium have different electrical charges, which may determine their ability to cause disease.

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