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Not used ▲to assess LYMErix? Yale's Congen Lyme
 
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24 May 2012 

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CDC writes a "bogus article" on Mycoplasma in the blood and Chronic Fatigue.
 

Lyme/LYMErix Cryme Reveals  New Paradigm in Health/Disease:
"Bacterial/Viral Coinfections";

TLR2 (fungi)Signaling Depletes IRAK1 and Inhibits Induction of Type 1 by TLR7/9  (viruses)-- 
-CV Harding, 2012  (More in the chart at the bottom of this homepage)

CFIDS = Seronegative Chronic Active EBV

"Multiple Mechanisms of Immune Suppression by B Lymphocytes" (New and Trashes Yale and IDSA)

NIH's Treatment Recommendations for Chronic Active Epstein-Borreliosis, the chronic illness also induced by OspA vaccination or exposure to molds.

The Antics of the Crazy Stalker Durland Fish and the New Genre in "Education."
 


CDC Greed (won't answer the FOIA)

ELISA = arbitrary cutoff.

Disclaimer

Overview


TUSKEGEE - By Jerry Leonard


1998, CIA Oilmen & Israelis plan to overthrow Saddam for the oil.

Bush/Gore  Oil/War-(Oct,2000)  

Bush's own explainer (Oct 2000) re: Iraq Oil




 

 

Most popular referred page 101009
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You are gonna laugh.

Look how many times Allen Steere, John Halperin, UCONN staff, and Yale staff, published about how serious "CHRONIC NEUROLOGIC LYME" was, but they now say there is no such thing as chronic Lyme, and that the "post-Lyme syndrome" is due to "catastrophising," hypochondria, depression, "medically unexplained symptoms," "some psychiatric illness," "Lyme Anxiety," "Lyme Paranoia," "Delusional Parasitosis," etc., and Mark Klempner says that people who respond positively to antibiotic treatment do so due to the "placebo effect."

ROFTL

[Remember now, we have for years asked friends and family to help us with the Lyme activism and they all either blew us all off, or reported to the DCF that we're "irresponsible parents because we go to the library"-  Nancy E. Martin, 21 Redstone Way. Farmington, Corrupticut.  ←More stuff you just can't make up.  That's recorded in depositions' transcripts. 

The New Haven FBI is too busy watching porn on the internet all day to drag themselves away from their porn monitors in New Haven, Corrupticut (at 600 State Street- an unmarked building), to help us, even though all of this is obvious to anyone with a brain in their head and wonders what will happen to them if a microscopic tick bites them and they don't see it- Porn and sleaze are very big in Corrupticut.  Just ask the former head of the DCF or one of the floozies down in New Haven DCF court who spend 3 hours a day in front of a mirror, instead of doing what I do, protecting children from Yale's crimes.  And just for the record, 75% of women fake orgasm, so AAG Jessica Gauvin only fools "judges," with her sex-o-metric behavior and Hollywood make-up studio get-up, since "judges" are inherently stupid and openly express hatred toward science-  Just ask Anton Scalia.

Nancy E. Martin has been on Bob Bransfield's MMI list since the Fall of 1999, since I thought she wanted to help people with chronic illnesses.  It turns out, she wants to file false allegations to DCF about them, and then perjure herself.  She has no children of her own.  God works in mysterious ways.  Nancy Martin is too selfish to be a mother.  She's like Gauvin.  You may be wondering why there are so many stupid people in Corrupticut...]

 

"Chronic Neurologic Lyme Disease," by Allen Steere, who now calls disease this "CRAZY."

  

 

 

 

 

  

 

http://www.nejm.org/doi/pdf/10.1056/NEJM199011223232102

1990 Steere using this seronegative Lyme Assay to evaluate "chronic neurologic Lyme" cases:

 

=====================

"The triad of neurological manifestations of Lyme disease," by Allen Steere and Andrew Pachner

 

   

   

 

Jeepers.  How did so many of us telepsychogenically hypochondriactomize the exact same chronic Lyme symptoms and the exact same markers of disease for so many years, even before we were the "internet cult??"

 

We have proof that UCONN's Louis Reik now says to patients that chronic neurologic Lyme is a non-entity and is hypochondria:

 

"Demyelinating encephalopathy in chronic neurologic Lyme Disease," by UCONN's Louis Reik, who now calls this disease, "CRAZY."

 

JJ Halperin-  Now says Chronic Neurologic Lyme is hypochondria, and this is despite knowing that the only true "seropositives" of chronic Lyme will only have a flagellin antibody, or band 41, since chronic Lyme blood testing is not Lyme Arthritis blood testing (Steere's knees-only disease), nor is it "Early Lyme blood" testing, due to antigenic variation.

A person who has had Lyme a long time will not have antibodies to a spirochete that just came out of a tick.  All the bugs continue to undergo antigenic variation and Andrew Pachner explains here about antigenic variation in brain-adapted spirochetes, and Alan Barbour explains here in his flagella-less Borrelia patent.  They all say that due to antigenic variation, all we can use to test for Lyme is a Borrelia-specific flagellin antibody method- the method that Yale did not use to validate LYMErix

 

"Lyme borreliosis-associated encephalopathy"--  JJ Halperin

 

 

Why Yale had a "Lyme and Lupus Clinic" before that became the biotech spinoff, "L2 Diagnostics," a central entity in the Lyme scientific fraud and racketeering organization. 

Most people (except MDs) know Lupus is a "neuropsychiatric" illness since antiphospholipid antibodies are also anti-brain antibodies.  Thus, Chronic Neurologic Lyme can't be hysteria or hypochondria, according to Allen Steere and Yale University, and it is malpractice to diagnose anyone with a DSM disorder without looking for these particular markers of real disease:

Anticardiolipin antibodies in neurologic Lyme, by Allen Steere:

  

  

 

http://www.geocities.com/kmdickson0308/lyme-dilemma.html

 

All of the scientifically valid markers of real disease were discovered by the Lyme crooks, themselves, but what they are and how to treat them are not listed in the IDSA Guidelines.

Gary Wormser was featured in "Ticks- The Real Vampires," a Discovery Channel Special, and in it he said, they do not know what are all the infections carried by ticks.

But they just know how to treat WE DON'T KNOW, and if you don't recover from WE DON'T KNOW disease treatment, Wormser et al say, "You never had WE DON'T KNOW disease."

 

Scientific fraud with intent to cause harm- deploying the idiots of psychiatry and the Munchausen's accusations, which is clearly a criminal act - a complaint to the United Nations Human Rights Commission in Geneva.

Four of us on ActionLyme performed the "Pick the Perps Operation," and recorded all the false statements made in the press by these criminals, and on the Perps Team was Barb Fitzmaurice who passed away 2 summers ago.   Barb was a great person and will always be remembered by me as one of the true heroes of The Lyme Wars.  I hate it when the Lyme people, especially the players like Barb, croak before we've won this war.  Gayla Davies passed away recently and she too was a big player for us.

Makes me FURIOUS.

 

"Telling women and girls inaccurately that they have Lyme disease "condemns patients to long-term, untreated debility and  useless, toxic and expensive courses of antibiotics," Sigal wrote  in an editorial in the May 15 issue of the journal Hospital Practice."--Emerging diseases // Ticks carry multitude of threats //
( Minneapolis Star Tribune ) Gordon Slovut; Staff Writer; 06-05-199  More at UN PETITION

Oh.

(The implication being that women have no penises and therefore an excess of The Twilight Zone.  See:  Yale Center for the Study of Erections )

 

Maybe they have actual scientists in Eurasia, Africa, and South America, who can query MedLine and see whether or not Roche claims these are pseudogallstones and therefore do not require surgery, since not a single MD in America apparently knows how to use MedLine. 

 

We female hypochondriactomizers have too much Twilight Zone and therefore rely on all the men to perform such research for us.  Maybe I can find a male around here to type in ceftriaxone and pseudolithiasis since I don't know how to spell them, myself. ...

Thanks, smart male hanging around.  I can't do this research myself because I have hyper-catastrophiziosis and therefore can't concentrate on anything other than my imaginary symptoms.

The IDSA Lyme guidelines are based on a "positive" test for Lyme (Klempner's Bogus Chronic Lyme "study"), when they all know the testing for Lyme is bogus and most of the crooks have reported that this testing is bogus themselves.

(Blumenthal has all their older reports which shows IDSA has committed scientific fraud, so what IDSA is excluding in the development of their guidelines is their own published data). 

But the central perp behind the bogus testing is Allen Steere, whose father worked in the insurance industry.  Steere dared to published that Lyme was "overdiagnosed" (sic) when he knows he pulled off the biggest medical scam in human history.

This is what he did:

Steere in Europe, using illegally high-passage strain G39/40.  Click the "Steere in Europe" link to see all of these reports and follow what he did.

Why did Steere go all the way to Europe to imaginate there should be no OspA and B antibodies in "Lyme Disease" after saying "Lyme disease" was too many antibodies against OspA  ???

 

http://iai.asm.org/cgi/reprint/56/8/1831?view=long&pmid=3397175  NIH Rocky Mountain Labs, including Willy Burgdorfer, say to use low passage strains to Western Blot because high passage strains drop plasmids- yet this is the high passage strain from which we got the Dearborn CDC criteria.

 

This is the CDC's Dearborn method:

http://www.cdc.gov/mmwR/preview/mmwrhtml/00038469.htm

Notice there is no band 31 (OspA) or 34 (OspB) listed.

 

That was the scam.  Steere's Imugen Lab, partners with Phil Molloy, and Yale's L2 Diagnostics, intended to be the only labs licensed to use the Dave Persing RICO method where they Western Blot with a strain with no OspA plasmid in it.  In this way, Steere and Yale and Corixa had a monopoly on the testing for Lyme, as well as the LYMErix vaccine royalties.

YouTube 12:50 mins   The Lyme and LYMErix RICO Patents - The Monopoly was set up around Yale's bogus LYMErix vaccine. 

The Yale scientifically valid way to test for Lyme is US Patent 5,618,533   The patent says the vast majority of all Lyme cases have this antiobody, band 41, or flagellin, so Yale made it SPECIFIC to Lyme borrelia, which is what one does in a method development and validation.

That means since 1991, Yale knew what was the scientifically valid way to diagnose Lyme, but we are still not allowed to use this method, which is MEDICAL NEGLIGENCE- the very thing disclaimed by ALDF/IDSA.

http://patft1.uspto.gov/ dot RICO dot monopoly dot 6045804

 

STEERE's ORIGINAL SERODIAGNOSTIC OBSERVATIONS:

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Using immunoblots, we identified proteins of Borrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were restricted primarily to a 41-kD antigen. This limited response disappeared within several months. In contrast, among six patients with prolonged illness, the IgM response to the 41-kD protein sometimes persisted for months to years, and late in the illness during arthritis, a new IgM response sometimes developed to a 34-kD component of the organism. The IgG response in these patients appeared in a characteristic sequential pattern over months to years to as many as 11 spirochetal antigens. The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=3531237

Get the full text and read every word.  I went through all of this step by step with the FBI but they could not take their noses away from all the porn they watch down there at 600 State Street, New Haven, CT.  I happen to think corporate crime is more interesting that porn, but then the Department of Justice is set up to protect corporate crime since they're republicans.

 

Go here to MedLine and look at all of Steere's earlier reports.  He clearly said Lyme disease was an arthritis in a knee caused by OspA-B  If you, the reader, have any self respect, you will look at all of those reports and wonder how we ended up with a standard test for Lyme which says if you have an antibody to OspA, you don't have Lyme disease.  The next question is, "Well, if OspA is specific enough to prevent Lyme, why isn't it specific enough to diagnose Lyme?"

% specificity of each band is equal to the accuracy of the test for each individual.  In order to increase the reliability of the test, they could go to capillary gel electrophoresis, since Western Blotting is so outdated, but you won't hear that from any MDs.  MDs are as bad as republicans.  It's a gang mentality.  A herd mentality.

 

You see, this is the crux of the Lyme crime.  The testing for Lyme is bogus, and they all know it, but they are preventing anyone from being treated for Lyme if the person doesn't have the positive bogus test (for Lyme arthritis).  This latest outburst by the very frightened of jail John Halperin is about a distraction over treatment outcomes, when the biggest bogus treatment outcome was Klempner's 2001 report.  I will be back later to debunk Klempner (again), line by line, word for word, exposing in particular the insane nonsense by Arthur Weinstein, since I did it for www.ILADS.org which has a Klempner debunker page on their website.  In other words, this crime has been a well-articulated  crime since 2001, but nothing has been done because the FBI and USDOJ prefer porn watching.

The Truth about Lyme Disease by the Infectious Diseases Society of America (IDSA)

BRAIN PARENCHYMA  (tissue) INVOLVEMENT- 1989.  ANDREW PACHNER

Title Page of Reviews of Infectious Disease, Supplement 6, 1989

 

 

 

Clinical Pathological Correlations of Lyme Disease

 

 

Immunological Aspects of Lyme Borreliosis- Ray Dattwyler and Ben Luft

 

 

How Lyme Borreliosis and LYMErix cause immune suppression illness, and why that has Bioweapons potential:

 "Signaling through TLR-2 by lipoproteins may represent a double-edged sword for host responses to chronic intracellular pathogens such as M. tuberculosis. Short-term signaling through TLR-2 activates macrophages and initiates acute inflammation that may help control initial infection. In contrast, prolonged TLR-2 signaling in macrophages results in down-regulation of certain critical immune functions, such as MHC-II Ag processing. M. tuberculosis infects, survives, and persists in macrophages. The ability of M. tuberculosis to survive acute inflammation positions the bacilli to take advantage, through secretion of lipoproteins such as LprG and LpqH, of this down-regulation of macrophage immune function."   http://www.jimmunol.org/cgi/content/full/173/4/2660    

 

TRANSLATION:  Downregulation of MHC-II Ag (antigen) processing means no antibodies are produced after a time (the chronic infection becomes "seronegative").

 

JJ Halperin served as an expert witness for SmithKline (committed perjury)

Halperin is seriously desperate about not going to jail since he knows he has published more than anyone, how serious Lyme disease is.  He knows he cannot retract all his previously published reports. ...

 

This is the CDC's Dearborn method:

http://www.cdc.gov/mmwR/preview/mmwrhtml/00038469.htm

 

Notice there is no band 31 (OspA) or 34 (OspB) listed.

 

Amazing, right?"

First Steere said, "Lyme is a disease of too many antibodies to OspA that cross-react with knee tissue," and then he said, "Oops, Um, No, I mean Lyme is everything BUT antibodies to OspA, so please take this OspA vaccine, since OspA antibodies is Lyme disease."

 And he dares to say *WE* have "some psychiatric illness?"

 

Here's the old 1990 CDC standard test for Lyme- which is Allen Steere's first standard - changing and expanding IgM and IgG antibodies, or that one should perform serial Western Blots, since Lyme is a relapsing fever borreliosis

 

It was because of this fact, that the testing for Lyme changed to suit the false-positive outcome of LYMErix, that AG Richard Blumenthal's staff lawyers referred me to US Attorney Kevin O'Connor to file the scientific fraud and racketeering complaint against Yale in July 2003.

 

What I told the FDA on January 31, 2001:

 

http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf 

Jan 31, 2001, KMDickson

 

 

YouTube Movie-   Listen to Mark Klempner, himself, discuss his "unpublished and not for large dissemination" HLA data re the genetic link between Lyme and Multiple Sclerosis  (HLA-DQB1*0602)  

 

 

You may be wondering how the nitrous oxide got into Allen Steere's neonatal rat brains so that Steere would publish in 1994 what he thinks is a scientifically valid explanation for ....

"Induction of NO synthase by bacterial agents within the brain may represent a common pathway of CNS inflammation and neurotoxicity.  PubMed ID # 7513330"

 

And then Steere later said we had "some psychiatric illness," rather than a real brain disease. 

 

 

Ol' Vijay Sikand of East Lyme, Corrupticut tawkin to da FDA 'bout how serious Lyme disease is at the 1998 FDA meeting about LYMErix. Later these crooks all claimed Lyme is imaginary:
http://www.fda.gov/ohrms/dockets/AC/98/transcpt/3422t1.rtf



"It is well known that Borrelia burgdorferi indeed after asymptomatic infection can lurk or secrete itself in certain areas of the body, perhaps the central nervous system or perhaps the joint spaces, only to reappear months or maybe years later in the form of late stages of illness which are harder to diagnosis and treat.

"It is probably worth noting, since I have learned a lot, that we don't have the clinical luxury in private practice that we had in the SmithKline Beecham trial in which we had baseline sera on all the patients who enrolled so that when they presented with symptoms, we could draw acute and convalescent serologies so as to compare them with each other and with baseline to better understand what symptoms they are presenting with.

"Finally, there are indeed many dilemmas in therapy. In particular, untreated or inadequately treated Lyme disease may lead to the chronic morbidity with which we are very familiar. Most commonly arthritis and the not common but complex neurological syndromes are what often result and which confront the primary care physician in the office diagnostically and therapeutically.

"These particular outcomes result in much more intensive, long-term expensive therapy, often in the form of long-term intravenous antibiotics. These are the patients who often are refractory to treatment. Indeed, these are the patients in whom symptoms seem to persist despite what we have given in terms of adequate antibiotic therapy by any known measure.

"In conclusion, we need a vaccine for Lyme disease because it is increasing in incidence and geographic spread. We need a vaccine for Lyme disease because there are problems in clinical diagnosis, its laboratory evaluation, and its treatment. We need a vaccine for Lyme disease because preventive measures are unfortunately ineffective. Lyme disease is indeed vaccine preventable. Availability of this vaccine would lead to a significant reduction in chronic sequelae and substantive morbidity. Lyme vaccine is thus a critical new public health approach to the primary prevention of Lyme disease in the United States. Thank you very much."--

Vijay Sikand, EAST LYME, CT

 

"But I, Vijay Sikand, also did not report adverse events to the FDA because Yale told me not to.  We're all secretly pretending spirochetes only infect knees.

 

 

Mycoplasma and Red Blood Cells- reports published in National Library of Medicine (formerly known as MedLine)

 

6190898  Among the Mycoplasma or stealth fungal infections studied at Plum Island....

Immunogenic variation among the so-called LC strains of Mycoplasma mycoides subspecies mycoides.   

Much evidence of immunogenic heterogeneity among the LC strains of Mycoplasma mycoides ssp. mycoides emerged from cross-immunization and -hyper-immunization experiments in mice in which three LC strains (Vom/Plum Island, 74/2488, and Mankefar 2833) were used for challenge purposes. All heterologous LC-strain vaccines cross-immunized against the three challenge strains, but protection was usually only 'partial', i.e. significantly less than that given by homologous vaccine. Cross-hyperimmunization with all heterologous LC but not SC strains produced protection against challenge with Vom/Plum Island that was virtually 'complete', i.e. similar to that produced by homologous vaccine. Challenge with 74/2488 gave generally similar results; but against Mankefar 2833 six heterologous LC vaccines gave complete protection and six did not. Vaccines prepared from the Smith (1423) strain of M. mycoides ssp. capri gave some protection against Vom/Plum Island but none against 74/2488 or Mankefar 2833. The cross-immunizing ability of three further M. mycoides ssp. capri strains appeared to resemble that of Smith (1423). In a cross-hyperimmunization experiment, vaccines prepared from SC strains of M. mycoides ssp. mycoides varied greatly in their ability to protect against challenge with strains 74/2488 and Mankefar 2833.   PMID: 6190898 [PubMed - indexed for MEDLINE]

 

 

 

"Lipoproteins and lipopeptides have been identified in a large number of microorganisms, the most prominent ones being mycobacteria, mycoplasms, and spirochetes. They have been found to exhibit both a strong innate inflammatory response in the host and an enduring adaptive immune response in mammalian hosts (16). The strong proinflammatory capacities of lipoproteins were first described for outer surface proteins A and B of Borrelia burgdorferi, which are also highly immunogenic (17) and have lately been the basis for a Lyme disease vaccine development (18). These compounds exhibit an triacylated lipid anchor structure comprising an N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl (Pam3Cys) moiety at the N terminus (19), a feature that was previously described for the Braun lipoprotein from Escherichia coli (20). Because the N-terminal Pam3Cys modification is essential for immunoactivation caused by lipoproteins of B. burgdorferi as well as of another spirochete, Treponema pallidum (21), subsequent studies investigating immune responses to spirochetes used synthetic lipopeptides (22). The Pam3Cys moiety was also reported to be present in cytokine-inducing lipoproteins of Mycobacterium and Mycoplasma spp. (23, 24); thus, it can be regarded as a highly conserved molecular motif among different classes of bacteria. In Mycoplasma fermentans, the presence of a macrophage stimulating lipopeptide, termed 2-kDa macrophage-activating lipopeptide (MALP-2), was observed, being stimulatory active at picomolar concentrations (25). This compound, in contrast to the predominant lipopeptide structures present in lipoproteins of E. coli, B. burgdorferi, and mycobacteria, lacks the N-palmitoyl group, thus containing a diacylated (Pam2Cys) lipid anchor structure at the N terminus. Following studies revealed the presence of closely related compounds in other Mycoplasma spp. (26).."    from:      http://www.jimmunol.org/cgi/content/full/173/4/2683

 

More on this type of immune suppression from MedLine

 

Must read:  http://www.jbc.org/cgi/content/full/274/47/33419  (UCONN's Justin Radolf)

"Toll-like receptors (TLRs) 2 and 4 are signal transducers for lipopolysaccharide, the major proinflammatory constituent in the outer membrane of Gram-negative bacteria. We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or TLR4. These TLR2-expressing cells were also stimulated by living motile B. burgdorferi, suggesting that TLR2 recognition of lipoproteins is relevant to natural Borrelia infection. Importantly, a TLR2 antibody inhibited bacterial lipoprotein/lipopeptide-induced tumor necrosis factor release from human peripheral blood mononuclear cells, and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge. The data suggest a role for the native protein in cellular activation by these ligands. In addition, TLR2-dependent responses were seen using whole Mycobacterium avium and Staphylococcus aureus, demonstrating that this receptor can function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through TLR2 and propose that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion."   http://www.jimmunol.org/cgi/content/full/173/4/2683