24 May 2012
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Natural Remedies
"Bacterial/Viral Coinfections";
TLR2 (fungi)Signaling Depletes IRAK1 and Inhibits Induction of Type 1 by TLR7/9 (viruses)-- -CV Harding, 2012 (More in the chart at the bottom of this homepage)
"Multiple Mechanisms of Immune Suppression by B Lymphocytes" (New and Trashes Yale and IDSA)
NIH's Treatment Recommendations for Chronic Active Epstein-Borreliosis, the chronic illness also induced by OspA vaccination or exposure to molds.
ELISA = arbitrary cutoff.
Disclaimer
1998, CIA Oilmen & Israelis plan to overthrow Saddam for the oil.
Bush/Gore Oil/War-(Oct,2000)
Bush's own explainer (Oct
2000) re:
Iraq Oil
BANNWARTH'S, SEE METHODS and NEGATIVE CUTOFF FOR CSF IgG (ain't what ya thought, for Europe)
Links to more pubs, below (MS/Lyme)
| Cellular Immunology Section |
|---|
Roland Martin, M.D., Investigator Dr. Martin received his medical training at the University of Würzburg, Germany, and prepared his M.D. dissertation with Jörg Draeger at the University of Hamburg, Germany. Following a post-doctoral fellowship with Hans-Wolfgang Kreth, Institute for Virology and Immunobiology, Würzburg, and a neurology residency with Hans-Georg Mertens, Department of Neurology, Würzburg, he received additional post-doctoral training with Henry McFarland, Neuroimmunology Branch, NINDS, studying cellular immunity in multiple sclerosis (MS). Dr. Martin joined the faculty at the Department of Neurology, Tübingen, Germany, with Johannes Dichgans, and conducted research in neuroimmunology. Dr. Martin continued his research at the Neuroimmunology Branch of the NIH and the Department of Neurology, University of Maryland at Baltimore with Kenneth Johnson. In 1997 he moved to the NINDS where he is the Acting Chief of the Cellular Immunology Section, Neuroimmunology Branch. He has received the Heinrich Pette Award of the German Neurological Association and a Heisenberg Professorship of the Deutsche Forschungsgemeinschaft. Dr. Martin's laboratory investigates the cellular immune system in multiple sclerosis and chronic Lyme disease and, together with Henry McFarland, develops novel treatment modalities for MS. |
 |
Staff:
- Bibiana Bielekova, M.D., Staff Clinician bielekob@ninds.nih.gov
- Gregg Blevins, M.D., Clinical Fellow blevinsg@ninds.nih.gov
- Erik Cabral, B.S., Student, (301) 496-0518
- Ricardo Cassiani-Ingoni, Ph.D., Postdoctoral Fellow cassanir@ninds.nih.gov
- Azita Kashani, B.S., Research Assistant, (301) 496-0518
- Dr. Paolo A. Muraro, M.D., Ph.D., Senior Research Fellow murarop@ninds.nih.gov
- Elisabetta Prat, M.D. prate@ninds.nih.gov
- Susan Scrivner, M.S., Research Assistant scrivners@ninds.nih.gov
- Mireia Sospedra, Ph.D., Postdoctoral Fellow sospedrm@ninds.nih.gov
- Xiang Wang, M.S., Senior Research Assistant, (301) 402-4488 wangxi@ninds.nih.gov
Research Interests:
| We are
interested in a better understanding of how the cellular immune system in
multiple sclerosis (MS) patients reacts to autoantigens of the central
nervous system. Our research includes studies on the molecular mechanisms
of T cell recognition, i.e. how T lymphocytes recognize antigens in the
context of MS-associated HLA-DR antigens, in particular HLA-DR15 Dw2.
These experiments address the functional and phenotypic repertoire of T
cells responding to various myelin antigens including myelin basic protein
(MBP), 2’3’-cyclic nucleotide-3’ phosphodiesterase (CNPase),
proteolipidprotein (PLP), myelin oligodendroglia glycoprotein (MOG), and
myelin oligodendroglia basic protein (MOBP), but also which foreign agents
may trigger autoreactive T cells via molecular mimicry. Through
collaborations, we develop novel methods to study molecular mimicry. Along
studies of the immunologic pathomechanisms of MS, we try to design new
immunotherapeuties based on the concepts evolving from the above work. It
is our final goal to develop these new therapeutic strategies until they
are applicable in MS patients and test them in phase I/II trials.
Candidate therapies which are currently being studied are altered peptide
ligands based on MBP peptide (83-99) as a highly specific
immunomodulation, phosphodiesterase type IV inhibitors to block
Th1-cytokines, and the administration of a humanized monoclonal antibody
against the IL-2 receptor a-chain expressed on activated T cells. In
treatment trials as well as in longitudinal studies of disease activity in
MS patients immunologic disease markers (measured by ELISA, quantitative
PCR, cDNA microarrays, T cell frequencies and specificity) are correlated
with the clinical course and disease activity as assessed by MRI. These
experiments shall not only help us to evaluate the efficacy of novel
treatments, but also try to prove the pathogenetic concepts derived from
animal studies. |
Selected Recent Publications:
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Kondo, T., Cortese, I., Markovic-Plese, S., Wandinger, K.-P., Carter, C., Brown, M., Leitman, S., Martin, R. (2001) Dendritic cells signal T cells in the absence of exogenous antigen., Nat. Immunol. 2, 932-938.
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Kondo, T., Cortese, I., Markovic-Plese, S., Wandinger, K.-P., Carter, C., Brown, M., Leitman, S., Martin, R. (2001) Dendritic cells signal T cells in the absence of exogenous antigen., Nat. Immunol. 2, 932-938.
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Bielekova, B., Goodwin, B., Richert, N., Kondo, T., Eaton, J., Afshar, G., Antel, J. Frank, J.A., McFarland, H.F., Martin, R. (2000) Encephalitogenic potential of myelin basic protein peptide (83-99) in multiple sclerosis – Results of a phase II clinical trial with an altered peptide ligand. , Nature Medicine 6, 1167-1175.
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Hemmer, B.*, Gran, B.*, Zhao, Y., Marques, A., Pinilla, C., Pascal, J., Tzou, A., Kondo, T., Cortese, I., Bielekova, B., Straus, S., McFarland, H.F., Houghten, R., Simon, R., Martin, R. (1999) Identification of candidate epitopes and molecular mimics in chronic Lyme disease. , Nature Medicine 5, 1375-1382.
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Hemmer, B., Fleckenstein, B, Vergelli, M., Jung, G., McFarland, H.F., Martin, R., Wiesmüller, K.-H. (1997) Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone., J. Exp. Med. 185, 1651-1659 .
Contact Information:
Dr. Roland Martin
Cellular Immunology Section
Neuroimmunology Branch, NINDS
Building 10, Room 5B16
10 Center Drive, MSC 1400
Bethesda, MD 20892-1400
Telephone: (301) 402-4488 (office), (301) 402-4488 (laboratory), (301) 402-0373 (fax)
Email: martinr@ninds.nih.gov
| Last updated Friday, September 13, 2002 Comments or questions? Send email to intrawebadmin@ninds.nih.gov |
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ROLAND MARTIN, MEDLINE: