09 Feb 2012
HOME
Pharma/CDC on Brain damage from vaccines, Fauci, Phages, Bioweapons manufacture
HHS.gov is Incompetent; BMJ calls fraud "crime.")
Official: CFIDS and MS-Lyme are the
same disease; Epstein-Barr
ELISA = arbitrary cutoff.
Disclaimer
1998, CIA Oilmen & Israelis plan to overthrow Saddam for the oil.
Bush/Gore Oil/War-(Oct,2000)
Bush's own explainer (Oct
2000):
Iraq Oil
Iraq was an oil-theft war.
"Catastrophizing"
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=11083273[uid]
"Telling women and girls inaccurately that they have Lyme disease 'condemns patients to long-term,
untreated debility and useless, toxic and expensive courses of antibiotics,' Sigal wrote in an editorial
in the May 15 issue of the journal Hospital Practice."--Emerging diseases // Ticks carry multitude of
threats // ( Minneapolis Star Tribune ) Gordon Slovut; Staff Writer; 06-05-199
More at UN PETITION4. Sigal and Shapiro Spinning Lyme for the Press (just gross)
http://www.geocities.com/kmdickson0308/1-4.txtFrom the Life on Earth Series: 9/15/00
(Linked or enclosed)
==================================
Reporting Sigal to his Medical Board, the American College of Rheumatology, and his employer, University of New Jersey Medical and Dental School. Sigal has since taken a job at a Pharmaceutical company, Bristol-Myers Squibb.
Please read the entire sequence of email correspondences. The Corruption and lies are clear and documented.
---- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Thu, 13 Feb 2003 18:04:15 -0500 To ajm@medicine.ucsf.edu, gsbsnadm@umdnj.edu, gsbspisc@umdnj.edu Subject [ILADS] LEONARD SIGAL
COMPLAINT FORM FOR NEW JERSEY MEDICAL EXAMINERS
http://www.state.nj.us/lps/ca/complaint/medcom.pdf
Greetings AJM and UMDNJ,
I am attaching the Connaught vaccine trial results
and Mr. Sigal's comments on the Lyme vaccine for children.
Principal Investigator, Leonard Sigal.
The following was published two years later.
We were wondering if you can tell us whether
there was a problem with this?
You can see that the summary of the results of
infection status was performed with the MarDx blot kits,
http://www.journals.uchicago.edu/CID/journal/issues/v31n1/991200/991200.html
(Sigal, Persing, Molloy and Berardi)
"Since specimen quantities were available, representative study subjects
were also tested by FDA-licensed ELISA and WB kits for descriptive and
comparative purposes, ***making no claim or attempt to formally validate
or invalidate these tests' performances for vaccinated study
subjects.***"
"Even when investigators are familiar with this phenomenon, problems
with interpretation of test results may arise in those situations when a
vaccinated subject actually becomes infected with B. burgdorferi (i.e.,
a vaccine failure)"
The manufacturer of the only currently FDA-approved (and released)
recombinant OspA Lyme disease vaccine has suggested that vaccination
does not interfere with serological evaluation of Lyme disease in
vaccine recipients [?] ***a statement that is not supported by the data
presented here.***
Serum samples from 10 additional study subjects that were obtained 30
days after dose 3 of a second recombinant OspA Lyme disease vaccine
(Pasteur Meriéux Connaught, Swiftwater, PA) were tested by the same
methodologies (data not shown). Similar findings of multiple bands
following vaccination were observed when tests with use of conventional
OspA-containing strains were done but not when tests with use of
OspA-free strains were done. This particular vaccine is not currently
licensed.
===================
I have another question, :
Chronic Lyme Disease: Sigal and Hassett's Response
Nowhere in our article (Sigal and Hassett 2002) do we minimize or
devalue the pain or suffering of patients with chronic Lyme disease nor
do we state that such patients are "crazy" or "delusional." Further, we
do not dismiss the possibility that some such patients actually have
infection that persists despite adequate prior antibiotic treatment.
Nonetheless, we take this opportunity to again issue a caution against
making the diagnosis of chronic Lyme disease in the absence of objective
clinical and microbiologic evidence of infection.
Without demonstrable physical findings and laboratory proof of the
persistence of Borrelia burgdorferi , the diagnosis should remain in
significant doubt. Certainly, a few, often poorly documented case
reports claiming persistence (many in Europe, where the organism, the
vector, and the ambient human immunogenetic types are different) cannot
be a basis for the widespread diagnosis of chronic infection in certain
regions of the United States and in certain practices.
We hope our article (Sigal and Hassett 2002) will help educate
physicians and assist them in being more sensitive to their patients and
to more correctly identify the true underlying cause of their patients'
symptoms in a compassionate manner. However, many patients are
misdiagnosed with chronic Lyme disease, a diagnosis often made to
provide an explanation for a bewildering array of complaints within an
acceptable framework for both patient and physician. Instead, these
patients deserve the truth. Improvement and cure require provision of a
correct scientific and medical explanation and properly directed
therapies. For many of the patients we see, chronic antibiotics,
continuous reassurance, and yet another antibiotic regimen when the
current one fails have led to frustration, anger, depression, and
chronic suffering. Further, the inappropriate use of broad spectrum
antibiotics, often for long periods, is not without personal (e.g.,
Clostridium dificile infection, allergies, and other adverse reactions)
and societal (e.g., contribution to the development of resistant strains
such as methicillin- and vancomycin-resistant Staphylococcus) risks.
Leonard H. Sigal
Afton L. Hassett
UMDNJ-Robert Wood Johnson Medical School
New Brunswick,New Jersey
E-mail: sigallh@umdnj.edu
Reference
But in Rahn and Evans' Lyme disease, ACP Key Diseases Series, 1998,
Mr Sigal writes:
"With widespread anxiety about Lyme disease has come
Munchausen Syndrome and Munchausen by proxy syndrome
in those concerned about "chronic" Lyme disease."-- page 149
I know that exactly says nothing, which Mr. Sigal is
an expert at (he was on the Debating Team in College,
he always mentions at conferences), but one might think...
Is he saying Lyme patients have Munchausens?
Okay, he never said Lyme patients were crazy or delusional.
I would argue that Munchausens could be considered a version
of "crazy".
-----------
And I was also wondering, since Allen Steere
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3531237&dopt=Abstract
and Dattwyler and Luft said changing IgM bands was evidence of
continuing
infection (Schutzer- Lyme Disease, Molecular and Immunologic
Approaches- page 319),
and then Mr. Sigal agrees:
"Previous studies demonstrated that specific antigen-antibody complexes
in the sera of patients with LD could be precipitated by polyethylene
glycol and could then be disrupted with maintenance of the
immunoreactivity of the released antibodies, that specific anti-B.
burgdorferi IgM was concentrated in ICs, and that occasionally IgM to
specific B. burgdorferi antigens was found in the IC but not in
unprocessed serum. EMIBA compared favorably with commercial and CDC
flagellin-enhanced enzyme-linked immunosorbent assays and other assays
in confirming the diagnosis of LD. EMIBA confirmed early B. burgdorferi
infection more accurately than the comparator assays. In addition, EMIBA
more accurately differentiated seropositivity in patients with active
ongoing infection from seroreactivity persisting long after clinically
successful antibiotic therapy; i.e., EMIBA identified seroreactivity
indicating a clinical circumstance requiring antibiotic therapy. Thus,
EMIBA is a promising new assay for accurate serologic confirmation of
early and/or active LD."
IgM means persisting infection, and patients can be seronegative,
How can Mr. Sigal report results of a vaccine trial,
when he knows the CDC's standard is inadequate?
========================
If Lyme disease becomes Fibromyalgia,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12194894&dopt=Abstract
and as Mr. Sigal says, IgG antibodies to Bb flagellin cross
react with human heat shock protein 60
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11860186&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8096152&dopt=Abstract
"As predicted, II-13 bound to mitochondria, in a pattern of cellular
binding very different from H9724, which bound in a scattered
cytoplasmic, nonorganelle-related pattern. ***H9724's effect is the
first evidence that HSP60 may play a role in peptide-hormone-receptor
function and demonstrates the modulatory potential of a monoclonal
antibody on living cells."***
and as Mr Sigal says in Schutzer's "Lyme disease" (page 208), IL-1
may be the cause of Fibromyalgia and sleep disorder associated with
and following "Lyme disease",
Does Mr Sigal test for these objective signs before
assigning the diagnosis of:
Environ Health Perspect 2002 Aug;110 Suppl 4:607-11 Related Articles,
Links
[Click here to read]
Contributions of societal and geographical environments to "chronic
Lyme disease": the psychopathogenesis and ***aporology*** of a new
***"medically unexplained symptoms"*** syndrome.
Sigal LH, Hassett AL.
New IgM, IgM Complexed, IgG antibodies to Flagellin,
IL-1 >>> all seemed to be diagnostic clues of REAL
ILLNESS, to Mr. Sigal, at one time.
Does Mr Sigal test for these before he diagnoses
UNEXPLAINED ILLNESS OR CONFUSION?
Is that required of a diagnostician?
Thanks, I hope you can help me out with this.
I was just wondering if that was what is meant by
Insurance Fraud. Or Fraud, of any kind.
I copied Mr. Sigal in. I know he can help me
out with this, because of the Debating experience.
First let's agree on the definitions of Fraud.
Mr. Sigal, start your dictionary!!!
2 entries found for fraud.
To select an entry, click on it.
Main Entry: fraud <http://www.m-w.com/images/audio.jpg>
Pronunciation: 'frod
Function: noun
Etymology: Middle English fraude, from Middle French, from Latin fraud-,
fraus
Date: 14th century
1 a : DECEIT, TRICKERY; specifically : ***intentional perversion of
truth in order to induce another to part with something of value*** or
to surrender a legal right b : an act of deceiving or misrepresenting :
TRICK
2 a : a person who is not what he or she pretends to be : IMPOSTOR; also
: one who defrauds : CHEAT b : one that is not what it seems or is
represented to be
synonym see DECEPTION, IMPOSTURE
------
One final consideration:
THE SCIENTIFIC METHOD
1. Observation and description of a phenomenon or group of phenomena.
2. Formulation of an hypothesis to explain the phenomena. In physics,
the hypothesis often takes the form of a causal mechanism or a
mathematical relation.
3. ***Use of the hypothesis to predict the existence of other phenomena,
or to predict quantitatively the results of new observations.***
4. Performance of experimental tests of the predictions by several
independent experimenters and properly performed experiments.
Does that mean, don't test for the markers
so you won't find them? Is that what a Medical
Scientist is? Do IgM, IgG to flagellin, IL-1
predict a non-diagnosis?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11083273&dopt=Abstract
Did Mr. Sigal validate the use of those
psychometric tests in the presence of these markers
of pathophysiology he has found in Lyme and post-Lyme Fibromyalgia?
Main Entry: im·pos·tor <http://www.m-w.com/images/audio.jpg>
Variant(s): or im·pos·ter <http://www.m-w.com/images/audio.jpg>
/im-'päs-t&r/
Function: noun
Etymology: Late Latin impostor, from Latin imponere
Date: 1624
: one that assumes false identity or title for the purpose of deception
Let me know if I should be asking somewhere else
for an explanation. My friends hate being called
crazy, or whatever is Mr. Sigal's latest popular
psychiatric diagnosis. It just isn't compassionate
at all, for a physici... Person who graduated
college and was on the debating team.
Thanks,
Kathleen Dickson
23 Garden Street
Pawcatuck, CT, 06379
----- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Thu, 13 Feb 2003 20:02:47 -0500 To acr@rheumatology.org, iversen@simmons.edu, cjhenderson@gsu.edu, backman@interchange.ubc.ca Subject [SpinLyme] Leonard Sigal UMDNJ-Robert Wood Johnson Medical School
New Brunswick,New Jersey
E-mail: sigallh@umdnj.edu
Greetings ACR,
I was looking around the web for an organization to report
ths misconduct of Leonard Sigal, UMDNJ. You must be it.
Sigal has a horrendous reputation as an Insurance Company
Reviewer, with tremendous bias against a set of patients
who do not even fall within his bailiwick. The reason for the
bias: That Lyme disease is just an arthritis, is because
he administered the Connaught vaccine trial, and as you know,
patients who bear the HLA-DR4 amd DR2 haplotypes are essentially
the arthritis-presenters.
The CDC set a conference in 1994 to standardize the serodiagnosis of
Lyme disease, and this was the IgG criteria:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8380611&dopt=Abstract
In the field, it was actually accurate 22% of the time.
Both vaccine trials were therefore fraudulent, since
one cannot throw out ~78% of one's data and call it
a study.
Would you please investigate the concerns below.
If his behavior is allowed to persist, he will ruin
the reputation of Rheumatology, as a scientific practice.
Sigal insists on patients having hard signs (lab) of
illness, meanwhile, he routinely assesses patients
on behalf of Insurance Companies, and reports without
seeking these objective determinations- ones he himself
developed. That is what it is looking like Rheumatology
is being reduced to. I am certain you will want to
maintain your reputations as practitioners, and discover
whether or not this behavior is true to the intended
nature of the study and treatment of connective tissue
diseases.
I am also attaching the Tick-Borne Diseases Management
Plan. You will see that the research included in that
is largely that of those who presented here:
http://rarediseases.info.nih.gov/news-reports/workshops/humanneuro20010909.html
Please investigate. This man really has hurt a *lot*
of people, and he just won't let up.
Thank You,
Kathlen Dickson
23 Garden Street
Pawcatuck, CT 06379
Subject:
[SpinLyme] LEONARD SIGAL
Date:
Thu, 13 Feb 2003 18:04:15 -0500
From:
Kathleen <kathleen.dickson@SNET.Net>
Reply-To:
SpinLyme@yahoogroups.com
Organization:
member, ActionLyme
To:
ajm@medicine.ucsf.edu, gsbsnadm@umdnj.edu,
gsbspisc@umdnj.edu
CC:
njinsurancefraud@njdcj.org, sigallh@umdnj.edu,
spinlyme@yahoogroups.com,
ilads@yahoogroups.com
COMPLAINT FORM FOR NEW JERSEY MEDICAL EXAMINERS
http://www.state.nj.us/lps/ca/complaint/medcom.pdf
Greetings AJM and UMDNJ,
I am attaching the Connaught vaccine trial results
and Mr. Sigal's comments on the Lyme vaccine for children.
Principal Investigator, Leonard Sigal.
The following was published two years later.
We were wondering if you can tell us whether
there was a problem with this?
You can see that the summary of the results of
infection status was performed with the MarDx blot kits,
http://www.journals.uchicago.edu/CID/journal/issues/v31n1/991200/991200.html
(Sigal, Persing, Molloy and Berardi)
"Since specimen quantities were available, representative study subjects
were also tested by FDA-licensed ELISA and WB kits for descriptive and
comparative purposes, ***making no claim or attempt to formally validate
or invalidate these tests' performances for vaccinated study
subjects.***"
"Even when investigators are familiar with this phenomenon, problems
with interpretation of test results may arise in those situations when a
vaccinated subject actually becomes infected with B. burgdorferi (i.e.,
a vaccine failure)"
The manufacturer of the only currently FDA-approved (and released)
recombinant OspA Lyme disease vaccine has suggested that vaccination
does not interfere with serological evaluation of Lyme disease in
vaccine recipients [?] ***a statement that is not supported by the data
presented here.***
Serum samples from 10 additional study subjects that were obtained 30
days after dose 3 of a second recombinant OspA Lyme disease vaccine
(Pasteur Meriéux Connaught, Swiftwater, PA) were tested by the same
methodologies (data not shown). Similar findings of multiple bands
following vaccination were observed when tests with use of conventional
OspA-containing strains were done but not when tests with use of
OspA-free strains were done. This particular vaccine is not currently
licensed.
===================
I have another question, :
Chronic Lyme Disease: Sigal and Hassett's Response
Nowhere in our article (Sigal and Hassett 2002) do we minimize or
devalue the pain or suffering of patients with chronic Lyme disease nor
do we state that such patients are "crazy" or "delusional." Further, we
do not dismiss the possibility that some such patients actually have
infection that persists despite adequate prior antibiotic treatment.
Nonetheless, we take this opportunity to again issue a caution against
making the diagnosis of chronic Lyme disease in the absence of objective
clinical and microbiologic evidence of infection.
Without demonstrable physical findings and laboratory proof of the
persistence of Borrelia burgdorferi , the diagnosis should remain in
significant doubt. Certainly, a few, often poorly documented case
reports claiming persistence (many in Europe, where the organism, the
vector, and the ambient human immunogenetic types are different) cannot
be a basis for the widespread diagnosis of chronic infection in certain
regions of the United States and in certain practices.
We hope our article (Sigal and Hassett 2002) will help educate
physicians and assist them in being more sensitive to their patients and
to more correctly identify the true underlying cause of their patients'
symptoms in a compassionate manner. However, many patients are
misdiagnosed with chronic Lyme disease, a diagnosis often made to
provide an explanation for a bewildering array of complaints within an
acceptable framework for both patient and physician. Instead, these
patients deserve the truth. Improvement and cure require provision of a
correct scientific and medical explanation and properly directed
therapies. For many of the patients we see, chronic antibiotics,
continuous reassurance, and yet another antibiotic regimen when the
current one fails have led to frustration, anger, depression, and
chronic suffering. Further, the inappropriate use of broad spectrum
antibiotics, often for long periods, is not without personal (e.g.,
Clostridium dificile infection, allergies, and other adverse reactions)
and societal (e.g., contribution to the development of resistant strains
such as methicillin- and vancomycin-resistant Staphylococcus) risks.
Leonard H. Sigal
Afton L. Hassett
UMDNJ-Robert Wood Johnson Medical School
New Brunswick,New Jersey
E-mail: sigallh@umdnj.edu
Reference
But in Rahn and Evans' Lyme disease, ACP Key Diseases Series, 1998,
Mr Sigal writes:
"With widespread anxiety about Lyme disease has come
Munchausen Syndrome and Munchausen by proxy syndrome
in those concerned about "chronic" Lyme disease."-- page 149
I know that exactly says nothing, which Mr. Sigal is
an expert at (he was on the Debating Team in College,
he always mentions at conferences), but one might think...
Is he saying Lyme patients have Munchausens?
Okay, he never said Lyme patients were crazy or delusional.
I would argue that Munchausens could be considered a version
of "crazy".
-----------
And I was also wondering, since Allen Steere
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3531237&dopt=Abstract
and Dattwyler and Luft said changing IgM bands was evidence of
continuing
infection (Schutzer- Lyme Disease, Molecular and Immunologic
Approaches- page 319),
and then Mr. Sigal agrees:
"Previous studies demonstrated that specific antigen-antibody complexes
in the sera of patients with LD could be precipitated by polyethylene
glycol and could then be disrupted with maintenance of the
immunoreactivity of the released antibodies, that specific anti-B.
burgdorferi IgM was concentrated in ICs, and that occasionally IgM to
specific B. burgdorferi antigens was found in the IC but not in
unprocessed serum. EMIBA compared favorably with commercial and CDC
flagellin-enhanced enzyme-linked immunosorbent assays and other assays
in confirming the diagnosis of LD. EMIBA confirmed early B. burgdorferi
infection more accurately than the comparator assays. In addition, EMIBA
more accurately differentiated seropositivity in patients with active
ongoing infection from seroreactivity persisting long after clinically
successful antibiotic therapy; i.e., EMIBA identified seroreactivity
indicating a clinical circumstance requiring antibiotic therapy. Thus,
EMIBA is a promising new assay for accurate serologic confirmation of
early and/or active LD."
IgM means persisting infection, and patients can be seronegative,
How can Mr. Sigal report results of a vaccine trial,
when he knows the CDC's standard is inadequate?
========================
If Lyme disease becomes Fibromyalgia,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12194894&dopt=Abstract
and as Mr. Sigal says, IgG antibodies to Bb flagellin cross
react with human heat shock protein 60
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11860186&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8096152&dopt=Abstract
"As predicted, II-13 bound to mitochondria, in a pattern of cellular
binding very different from H9724, which bound in a scattered
cytoplasmic, nonorganelle-related pattern. ***H9724's effect is the
first evidence that HSP60 may play a role in peptide-hormone-receptor
function and demonstrates the modulatory potential of a monoclonal
antibody on living cells."***
and as Mr Sigal says in Schutzer's "Lyme disease" (page 208), IL-1
may be the cause of Fibromyalgia and sleep disorder associated with
and following "Lyme disease",
Does Mr Sigal test for these objective signs before
assigning the diagnosis of:
Environ Health Perspect 2002 Aug;110 Suppl 4:607-11 Related Articles,
Links
[Click here to read]
Contributions of societal and geographical environments to "chronic
Lyme disease": the psychopathogenesis and ***aporology*** of a new
***"medically unexplained symptoms"*** syndrome.
Sigal LH, Hassett AL.
New IgM, IgM Complexed, IgG antibodies to Flagellin,
IL-1 >>> all seemed to be diagnostic clues of REAL
ILLNESS, to Mr. Sigal, at one time.
Does Mr Sigal test for these before he diagnoses
UNEXPLAINED ILLNESS OR CONFUSION?
Is that required of a diagnostician?
Thanks, I hope you can help me out with this.
I was just wondering if that was what is meant by
Insurance Fraud. Or Fraud, of any kind.
I copied Mr. Sigal in. I know he can help me
out with this, because of the Debating experience.
First let's agree on the definitions of Fraud.
Mr. Sigal, start your dictionary!!!
2 entries found for fraud.
To select an entry, click on it.
Main Entry: fraud <http://www.m-w.com/images/audio.jpg>
Pronunciation: 'frod
Function: noun
Etymology: Middle English fraude, from Middle French, from Latin fraud-,
fraus
Date: 14th century
1 a : DECEIT, TRICKERY; specifically : ***intentional perversion of
truth in order to induce another to part with something of value*** or
to surrender a legal right b : an act of deceiving or misrepresenting :
TRICK
2 a : a person who is not what he or she pretends to be : IMPOSTOR; also
: one who defrauds : CHEAT b : one that is not what it seems or is
represented to be
synonym see DECEPTION, IMPOSTURE
------
One final consideration:
THE SCIENTIFIC METHOD
1. Observation and description of a phenomenon or group of phenomena.
2. Formulation of an hypothesis to explain the phenomena. In physics,
the hypothesis often takes the form of a causal mechanism or a
mathematical relation.
3. ***Use of the hypothesis to predict the existence of other phenomena,
or to predict quantitatively the results of new observations.***
4. Performance of experimental tests of the predictions by several
independent experimenters and properly performed experiments.
Does that mean, don't test for the markers
so you won't find them? Is that what a Medical
Scientist is? Do IgM, IgG to flagellin, IL-1
predict a non-diagnosis?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11083273&dopt=Abstract
Did Mr. Sigal validate the use of those
psychometric tests in the presence of these markers
of pathophysiology he has found in Lyme and post-Lyme Fibromyalgia?
Main Entry: im·pos·tor <http://www.m-w.com/images/audio.jpg>
Variant(s): or im·pos·ter <http://www.m-w.com/images/audio.jpg>
/im-'päs-t&r/
Function: noun
Etymology: Late Latin impostor, from Latin imponere
Date: 1624
: one that assumes false identity or title for the purpose of deception
Let me know if I should be asking somewhere else
for an explanation. My friends hate being called
crazy, or whatever is Mr. Sigal's latest popular
psychiatric diagnosis. It just isn't compassionate
at all, for a physici... Person who graduated
college and was on the debating team.
Thanks,
Kathleen Dickson
23 Garden Street
Pawcatuck, CT, 06379
----- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Fri, 14 Feb 2003 04:51:23 -0500 To acr@rheumatology.org, iversen@simmons.edu, cjhenderson@gsu.edu, backman@interchange.ubc.ca Subject [scilyme] Leonard Sigal 2
Part 2 of the complaint regarding Sigal's "authority"
in "Lyme disease".
SIGAL:
"At the December 1994 National Clinical Conference on Lyme Disease, 10
experts presented the clinical state of the art on the infection. Panel
discussions followed, allowing for interchange with clinicians. The
conference was sponsored by the UMDNJ Center for Continuing Education
and the American Lyme Disease Foundation, Inc.; it was underwritten by
Connaught Laboratories, Inc."
http://www.umdnj.edu/umcweb/hstate/aut96/aug96lym.html
Do you think this is a conflict, since Sigal then went on to
be the Connaught trial administrator?
IS THIS TRUE?
"The serologic and molecular biologic diagnostic tests are as accurate
as most such tests for infectious disease, but they should be used only
with a full understanding of their limitations."
Or, rather, does it make sense?
The conceptual framework of Sigal, to put it nicely,
is that only 1) one spirochete, one with lipoprotein-code-bearing
plasmids that are similar to those found in B burgdoferi (as
defined by the presence of the OspA plasmid) can produce
disease, 2) that disease manifests as a reactive arthritis,
and 3) it only lasts one month, since antibiotics "kill"
spirochetes in vitro.
http://www.geocities.com/kmdickson0308/1-4.txt
"SIGAL: Nobody has ever found a Borrelia Burgdorfer that is resistant to
the standard antibiotics that are used in the treatment of Lyme Disease.
Which I think really
pokes a major league hole in the theory that what you've got is you need
more antibiotics because you've made a super-bug."
Nobody in the professional Lyme disease arena ever said anything about a
super bug. As you will see below, in vitro, is not the same thing as
in vivo (Klempner). The argument is, that spirochetes behave like
spirochetes.
The argument is that they sequester (latency, asymptomatic, starvation
forms,
spheroplasts, stringent forms, "cysts", "morphometrics") in antibiotic
and immune privileged sites, and that patients need to be retreated when
they
are symptomatic.
If it is not true, as Sigal says in the article above, that Lyme
is a Great Imitator, "Lyme disease was incorrectly called "The Great
Imitator"
because of its apparent ability to mimic other diseases, one wonders
what other disease syndromes are possibly left out here of the
representations
are left out of the multitissue tropism and immune dysregulation
discussed
below?
1) Zentralbl Bakteriol Mikrobiol Hyg [A] 1986 Dec;263(1-2):201-5
Clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH,
Pachner AR, Rahn DW,
***Sigal LH***, Taylor E, Malawista SE.
Lyme disease typically begins with a unique skin lesion, erythema
chronicum migrans (ECM) (stage 1). Patients with this lesion may also
have headache, meningeal irritation, mild encephalopathy, multiple
annular secondary lesions, malar or urticarial rash, generalized
lymphadenopathy and splenomegaly, migratory musculoskeletal pain,
hepatitis, sore throat, non-productive cough, conjunctivitis,
periorbital edema, or testicular swelling. After a few weeks to months
(stage 2), about 15% of patients develop frank neurologic abnormalities,
including meningitis, encephalitis, cranial neuritis (including
bilateral facial palsy), motor or sensory radiculoneuritis, mononeuritis
multiplex, or myelitis. At this time, about 8% of patients develop
cardiac involvement--AV block, acute myopericarditis, cardiomegaly, or
pancarditis. Throughout this stage, many patients continue to experience
migratory musculoskeletal pain in joints, tendons, bursae, muscle, or
bone. Months to years after disease onset (stage 3), about 60% of
patients develop frank arthritis, which may be intermittent or chronic.
Recently evidence suggests that Lyme disease may also be associated with
chronic neurologic or skin involvement. Thus, Lyme disease occurs in
stages with different clinical manifestations at each stage, but the
course of the illness in each patient is highly variable.
PMID: 3554839 [PubMed - indexed for MEDLINE]
2) Semin Neurol 1997 Mar;17(1):63-8 Related Articles, Links
Immunologic mechanisms in Lyme neuroborreliosis: the potential role
of autoimmunity and molecular mimicry.
***Sigal LH.***
Department of Medicine and Disease Center, University of Medicine
and Dentistry of New Jersey-Robert Wood Johnson Medical School, New
Brunswick 08903-0019, USA.
Most of the clinical manifestations of Lyme disease are due to the
local presence of the causative agent, Borrelia burgdorferi, in the
affected tissues. However, the precise means of tissue damage are not
well understood and there is no proof that the organism, live or dead,
is always present. An understanding of the complex interaction between
the organism, the immune response elicited by the organism, and the host
can explain manifestations of the disease and persistence of symptoms
and signs after the antibiotic-induced death of the organism. It is
possible that dead spirochetes, or fragments thereof may persist and act
as a focus of ongoing inflammation. Different immunogenetic types may
predispose to different immunologic responses, with distinct clinical
outcomes. Vascular changes induced by the infection, either by local
infection or the effects of cytokines on the vessel wall, may underlie
tissue pathology. Finally, the immune response to B. burgdorferi may
elicit the production of antibodies capable of recognizing and damaging
or modifying normal host tissues. ***Only by establishing the mechanisms
causing tissue damage in Lyme disease can rational therapeutic
strategies be developed.*** Only by understanding these mechanisms can
physicians and patients interpret clinical responses to therapy and
accurately appreciate the clinical prognosis.PMID: 9166962 [PubMed -
indexed for MEDLINE]
I think that means, there are still unknowns. I think that means
Sigal knew this was the case, before the start of the Connaught trials,
and his statements regarding the completed framework of all outcomes
of "Lyme disease" are false, particularly since it is yet unknown, what
are the clinical syndromes associated with antibodies which
"cross-react"
with host antigens (antiflagellin antibodies and Human Heat Shock
Protein 60-
Sigal's work), and what is the result of persisting dysregulated
cytokines.
========
PERSISTENCE PAST TREATMENT (latency, asymptomatic, etc):
http://www.acponline.org/journals/annals/15mar94/acids.htm
http://www.acponline.org/journals/annals/15oct94/lyme.htm
STEERE:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8272083&dopt=Abstract
(You have to get the full text of that. Figure 1 shows
10 patients had persisting DNA after treatment--and only via
these primers; 'will get back to primers later-- up to 7 years,
which was the upper time limit of the study)
LOBET at the FDA's Vaccine meeting:
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2.htm
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_02_lobet.pdf
KLEMPNER:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1634816&dopt=Abstract
STRAUBINGER (ANTIBIOTIC- TREATED DOGS):
http://jcm.asm.org/cgi/reprint/35/1/111.pdf
COYLE (Relapsing Neuroborreliosis- Seronegative):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7796837&dopt=Abstract
SYPHILITIC LATENCY:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10780185&dopt=Abstract
LYMErix vaccine trial results:
http://www.fda.gov/ohrms/dockets/ac/01/slides/3680s2_11.pdf
or
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9673298&dopt=Abstract
see the charts, the data. Few "asymptomatics" in the vaccine groups,
while
increasing "Unconfirmed Lyme"-- raises a red flag. Such tabulation
of results was not published for Connaughts trial.)
"SEEDING"
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7501150&dopt=Abstract
Starvation Forms, Morphometrics:
BURGDORFER:
http://www.radio.cbc.ca/programs/ideas/shows/bacteria/willy.html
('references the Brorsons)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9266264&dopt=Abstract
NELSON:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12511489&dopt=Abstract
BARBOUR:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7103461&dopt=Abstract
MARGULIS ("morphometrics"):
http://www.pnas.org/cgi/reprint/90/15/6966.pdf
US ARMY (aerosolized leptospira):
http://www.afpmb.org/pubs/dveps/haiti.pdf
Lastly, spirochetes are parasites. There apparently limitless
variations in
surface antigens of the Borreliae, and the evidence does not all support
the
notion that the B. burgdorferi is stable, predictably generates
invariable
antigen (and thus inflammatory effects - in fact, it is characterized
by just the opposite), that B. burgdorferi is even a distinct species,
or
that it is the only one which produces disease in humans and is vectored
only by Ixodes.
http://coproweb.free.fr/pagbac/borrelia.htm
see
http://www.pasteur.fr/recherche/borrelia/Group_DN127.html
STARI-- Texas to NJ
http://www.cdc.gov/ncidod/eid/vol7no3/burkot.htm
http://www.cdc.gov/ncidod/dvbid/stari/
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8573491&dopt=Abstract
Int J Syst Bacteriol 1996 Jan;46(1):167-72
Analysis of the genetic polymorphism of Borrelia burgdorferi sensu
lato by multilocus enzyme electrophoresis.
Balmelli T, Piffaretti JC.
Istituto Cantonale Batteriosierologico, Lugano, Switzerland.
***The relapsing fever spirochetes were were
not clearly separated from the spirochetes associated with Lyme
disease.*** In conclusion, we believe that ***the previously proposed
subdivision of B. burgdorferi sensu lato into only four species should
be reconsidered.*** PMID: 8573491 [PubMed - indexed for MEDLINE]
Related:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Display&dopt=pubmed_pubmed&from_uid=8573491
phylogenetic analysis of rRNA genes
http://jcm.asm.org/cgi/reprint/33/9/2427.pdf
Int J Syst Bacteriol 1996 Oct;46(4):898-905
Phylogenetic analysis of Borrelia species based on flagellin gene
sequences and its application for molecular typing of Lyme disease
borreliae.
Fukunaga M, Okada K, Nakao M, Konishi T, Sato Y.
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama
University, Hiroshima, Japan. mfukunag@supernig.nig.ac.jp
We determined almost complete flagellin gene sequences of various
Borrelia species and aligned them with previously published sequences. A
neighbor-joining phylogenetic analysis showed that the genus Borrelia
was divided into the following three major clusters: New World relapsing
fever borreliae (Borrelia turicatae, Borrelia parkeri, and Borrelia
hermsii), Old World relapsing fever borreliae (Borrelia crocidurae,
Borrelia duttonii, and Borrelia hispanica), and Lyme disease borreliae
(Borrelia burgdorferi sensu stricto, Borrelia garinii, and Borrelia
afzelii). Agents of animal spirochetosis (Borrelia coriaceae and
Borrelia anserina) and species of unknown pathogenicity (Borrelia
miyamotoi and Borrelia lonestari) were related to relapsing fever
borreliae. Although the Lyme disease borreliae, two related species
(Borrelia japonica and Borrelia andersonii), and some newly described
genomic groups (groups PotiB2, VS116, DN127, Hk501, and Ya501) were
closely related to each other, each taxon formed an independent branch
on the phylogenetic tree. The data obtained in this study indicate that
the flagellin genes are useful in Borrelia taxonomy. To distinguish the
Lyme disease borreliae from related organisms easily, we designed an
oligonucleotide primer set for the flagellin gene and performed a
PCR-restriction fragment length polymorphism (PCR-RFLP) analysis. The
primer set amplified an approximately 580-bp DNA fragment that included
species-specific restriction sites, and HapII, HhaI, CelII, HincII, or
DdeI digestion of the product resulted in distinctively different
PCR-RFLP patterns. The PCR-RFLP typing method which we developed should
facilitate rapid identification of Lyme disease borreliae and related
organisms obtained from biological and clinical specimens.
PMID: 8863416 [PubMed - indexed for MEDLINE]
DURLAND FISH:
http://www.yale.edu/opa/v29.n29/story8.html
"It is completely cryptic, which means there is no way to diagnose it,"
Fish says. "None of the Lyme disease tests would detect an infection by
this organism.
UNKNOWNS/COINFECTIONS (in addition to viral, bacterial knowns)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12459246&dopt=Abstract
J Microbiol Methods 2003 Feb;52(2):251-60
Application of broad-range 16S rRNA PCR amplification and DGGE
fingerprinting for detection of tick-infecting bacteria.
"Two sequences were related to the yet to be cultivated Haemobartonella.
To our knowledge, Haemobartonella has never been directly detected in I.
ricinus.
"In addition, members of the genera Staphylococcus, Rhodococcus,
Pseudomonas, and Moraxella were detected, which have not been identified
in ticks so far.
"Two bacteria were most closely related to a rickettsial endosymbiont of
an Acanthamoeba sp., and to an endosymbiont (Legionellaceae, Coxiella
group) of the microarthropod Folsomia candida.
MEDIA: Does BSK represent reality?
http://peer1.nasaprs.com/peer_review/taskbook/micro/mg00/agreement.html
Progress Report: We have conducted multiple trials to explore the
feasibility of cultivating the Borrelia burgdorferi, under ex-vivo
conditions in the RWV utilizing human tissue substrates. We have shown
that RWV cultures: a) allow maintained growth of low passage Borrelia
burgdorferi spirochetes in RWVs (manuscript in preparation), b) permit
the colonization of human tissue samples co-cultivated with the
microorganisms (Figures 6 & 7) and c) allow exponential increases in the
numbers of spirochetes in far greater numbers compared to current
methods existing in the literature. Numerous experiments were done
utilizing controls, inhibition steps, and culture medium trials with and
without the RWV, with the best results obtained using human tonsillar
tissue substrates and RPMI medium for growth up to 28-30 days. Tissue
biopsies from patients with Lyme disease have been cultured in RWVs to
look for proliferation of spirochetes in primary infected tissue. The
RWV has also been used to culture normal human tissues with Borrelia, to
study the infection process.
======
It's quite simple: Borrelial infections in humans can't be fully
described, regardless of one's need to be an Insurance Company Reviewer,
or Prinicipal Investigator of a lipoprotein vaccine for one strain of B.
burgdorferi. Host selection pressures, coinfections, the inherent
"instability" of the genus, unknown coinfections, phage-vectored plasmid
exchange, resistence, morphological forms, incompletely descibed
vector-ranges and vector competence, global warming, and the inherently
unpredictable response in any human individual, don't support the
notion:
http://www.umdnj.edu/umcweb/hstate/aut96/aug96lym.html
"The clinical manifestations of Lyme disease are now well described. It
is not, and has never been, a mimic of all syndromes and diseases."
Silliness.
Kathleen M. Dickson
23 Garden Street
Pawcatuck, CT 06379
----- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Fri, 14 Feb 2003 09:34:20 -0500 To Arthur.Weinstein@Medstar.net Subject [ILADS] Re: Leonard Sigal 2
Arthur.Weinstein@Medstar.net wrote:
>
> Kathleen
>
> Without entering into polemics and personalities, the only issue I would
> make is that one cannot always infer that persistent or recurrent symptoms
> are caused by persistent or recurrent infection. There are many examples
> in medical illness, including other infectious diseases, where a percentage
> of patients develop chronic symptoms and yet the original trigger, be it an
> organism or other, has been eradicated from the body. The mechanism of
> this clinical phenomenon is in many cases ill understood and efforts should
> be made to study it so that rational, scientifically-based treatment can be
> administered.
>
> Arthur Weinstein, MD
> Professor of Medicine
> Georgetown University Medical Center
> Director, Section of Rheumatology, #2A-66
> Washington Hospital Center
> 110 Irving St, NW
> Washington, DC 20010
> Tel: 202-877-6274
> Fax: 202-877-6130
> Pager #5412
My statement on the state of the illness is attached.
You will find I agree with you that infection alone is
not a/the primary disorder.
The fact is Lenny has used the following statements
to characterize us:
"Lyme Anxiety", "Munchausens's", "Antibiotics are
Poison", "Aporology", "Unexplained Medical Illness",
"Catatrophizing", "Women and girls should not be
told they have Lyme disease"...
Another important fact is that you "validated"
the Fibromyalgia Impact Questionaire to be used
by Klempner in his NIH "study"; this was performed/reported
AFTER the study was started, and it showed the etiologies
were different. So that is not a validation.
We also know that you thought you had to come down
to Valhalla and teach people about seroassay for
Lyme antibodies, and that you said Dressler/Steere
(Dearborn IgG) was valid, because loud blots are loud.
People in their right minds want their disease to
be detected and treated. That would *mean* increase
sensitivity. That would *mean* loud blots being loud
is... not thinking of the best interest of the patients.
We know you were on the Dearborn Committee to approve
Dressler, and we know this was not a consensus, although
participants who were invited, were led to believe it
would be a consensus meeting. This is not hearsay.
If you want to talk about other illnesses that are
similar to Lyme, I am sure you always execute the
validated clinical analyses, some of which are
listed in the attached management plan, to determine
objectively, pathophysiology.
The point is exactly, to do otherwise, to pretend
your expertise in clinical exam gives you license to
transcends into the domain of unsubtantiated,
pathophysiologically, psychiatric syndromes, and
that people can't detect the fallacy in this, means
your Rheumatology Mates have a harder row to hoe,
in terms of re-establishing any respect for your
genre.
We patients have done more good, have helped more
Fibromyalgia/CFIDS patients, than any Rheumatologist in
CT, and that may be true for New York as well.
It's not that tough. We just help. We care.
I think that may give you some consideration over
whether or not were are somatizing, preoccupied with
symptoms, ... or whatever other characterizations
Rheumatologists seem to have in mind for a therapeutic
strategy.
I agree with what you say above: "Lyme disease"
is not simply a spirochetal infection. It's not
like, a "septic arthritis in the knee", as Klempner
says. *You* may believe it is so, because your mates,
and Steere, defined it that way in order to sell a few
vaccines, and to bring business to L2 Diagnostics
and Imugen. If you want to maintain that Lyme disease is a
simple as a boo-boo, why does the ALDF have such well-positioned
(on Wall Street) individuals on its Board of Directors?
Why is Ray Dattwyler's office/Company/Biotaech Incubator
in the same place as NYBA.org Administrative Offices?
Why is Kemp Hannon against OPMC reform?
Because Borreliosis and related Gold Mines of Biotechnology
truely cannot be defined. In the case of Lyme disease,
a spirochetal infection became 5 of 10 bands and a knee.
Field studies showed 22-25% accuracy of Dressler.
The vaccine was 76% "safe" and "effective".
Because 100- (22-25) of the data was thrown out.
("Unconfirmed Lyme")
Politically. Only.
Falsely.
To suit the intended outcome of the biocommercial
product. And Lenny is the MouthPiece. And it is
no surprise to us, that you might try to defend him.
First, Do No Harm.
When you start demonstrating a respect for patients,
humans, you may gain some self respect.
Perhaps you can start with "What does OspA do in
an Asymptomatic infection?" And answer that honestly.
Kathleen Dickson
----- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Fri, 14 Feb 2003 09:44:52 -0500 To Arthur.Weinstein@Medstar.net Subject [ILADS] I forgot... This is Sigal_1... was...Re: Leonard Sigal 2 Since you are a blot expert, what happened here,
and why did the trials go forward?
http://www.journals.uchicago.edu/CID/journal/issues/v31n1/991200/991200.html
(Sigal, Persing, Molloy and Berardi)
"Since specimen quantities were available, representative study subjects
were also tested by FDA-licensed ELISA and WB kits for descriptive and
comparative purposes, ***making no claim or attempt to formally validate
or invalidate these tests' performances for vaccinated study
subjects.***"
"Even when investigators are familiar with this phenomenon, problems
with interpretation of test results may arise in those situations when a
vaccinated subject actually becomes infected with B. burgdorferi (i.e.,
a vaccine failure)"
The manufacturer of the only currently FDA-approved (and released)
recombinant OspA Lyme disease vaccine has suggested that vaccination
does not interfere with serological evaluation of Lyme disease in
vaccine recipients [?] ***a statement that is not supported by the data
presented here.***
Arthur.Weinstein@Medstar.net wrote:
>
> Kathleen
>
> Without entering into polemics and personalities, the only issue I would
> make is that one cannot always infer that persistent or recurrent symptoms
> are caused by persistent or recurrent infection. There are many examples
> in medical illness, including other infectious diseases, where a percentage
> of patients develop chronic symptoms and yet the original trigger, be it an
> organism or other, has been eradicated from the body. The mechanism of
> this clinical phenomenon is in many cases ill understood and efforts should
> be made to study it so that rational, scientifically-based treatment can be
> administered.
>
> Arthur Weinstein, MD
> Professor of Medicine
> Georgetown University Medical Center
> Director, Section of Rheumatology, #2A-66
> Washington Hospital Center
> 110 Irving St, NW
> Washington, DC 20010
> Tel: 202-877-6274
> Fax: 202-877-6130
> Pager #5412
----- Original Message ----- From Kathleen <kathleen.dickson@SNET.Net> Date Fri, 14 Feb 2003 17:55:29 -0500 To ILADS@yahoogroups.com Subject [EuroLyme] Leonard Sigal 3 "Aporia. No way out, nothingness, or the impenetrable. It is something
which is not porous which cannot leak. The interlocutors in the early
Platonic dialogues cannot get out of the dead-ends into which Socrates
leads them. They are in aporia; hence, the locution "aporetic"
dialogues, the early dialogues where there seems to be no positive
result."
We *definitely* know who's stuck in a loop
around here, and it isn't the patients:
SIGAL:
http://ehpnet1.niehs.nih.gov/docs/2002/suppl-4/607-611sigal/abstract.html
Lyme disease is a relatively well-described infectious disease with
multisystem manifestations. Because of confusion over conflicting
reports, anxiety related to vulnerability to disease, and
sensationalized and inaccurate lay media coverage, a new syndrome,
"chronic Lyme disease," has become established. Chronic Lyme disease is
the most recent in a continuing series of "medically unexplained
symptoms" syndromes. These syndromes, such as fibromyalgia, chronic
fatigue syndrome, and multiple chemical sensitivity, meet the need for a
societally and morally acceptable explanation for ill-defined symptoms
in the absence of objective physical and laboratory findings. We
describe factors involved in the psychopathogenesis of chronic Lyme
disease and focus on the confusion and insecurity these patients feel,
which gives rise to an inability to adequately formulate and articulate
their health concerns and to deal adequately with their medical needs, a
state of disorganization termed ***aporia***. Key words: aporology,
chronic Lyme disease, Lyme disease, medically unexplained symptoms,
misdiagnosis, psychological, psychopathogenesis. Environ Health Perspect
110(suppl 4):607-611 (2002).--
We all are aware of the motive for shifting
borreliosis into the catagory "Medically Unexplained"-
Declare "Chronic Lyme Disease" to be an entity with no
markers, no evidence, such that no discovery is attempted,
and therefore no medical treatment or cost to Managed Care.
It's already been established that Sigal has
drawn in terms like Munchausens and so forth,
but a short history of the confusion Sigal has
spun, and why his problems have been apparently
projected into patients:
"It could be the fibromyalgia, but you cannot assume it is Lyme
disease. Or it could
be Lyme disease, but you should not assume it is the fibromyalgia":
-Leonard H. Sigal, MD, in American Journal of Medicine, vol. 98, suppl.
4A
"Tertiary neuroborreliosis can be differentiated from the early
disseminated
neurological disease by the fact that it is later, very frequently in
association with
inflammatory joint disease, but quite frequently it will be on its own,
and sometimes
it will be the very first manifestation of Lyme disease":
-Leonard H. Sigal, MD, Chief, Division of Rheumatology, Robert Wood
Johnson Medical
School, New Brunswick, N.J., in his paper read at Yale's 6th Annual Lyme
Disease
Symposium, June 16, 1993
"Lyme disease, although a problem, is not nearly as big a problem as
most people
think." The bigger epidemic," Dr. Sigal said, "is Lyme anxiety." And, he
said, "even if
you get the disease, it is easily treatable and it is curable."
- Leonard H. Sigal, MD, Quoted by Gina Kolata in New York Times, June
13, 2001
NEW YORK TIMES QUOTE OF THE DAY: "Antibiotics are Poison"-- Lenny Sigal
(6-13-01)
=======
"In practicing medicine we must demand objective findings to diagnose
patients; we must develop and use diagnostic criteria; and we must
include the possibility of intercurrent disease or evolution of the
process in our ongoing analysis of patients. ...
...A new diagnosis has emerged, "pseudo-LD", to coin a term. It
describes
the certainty that LD is present when there is no verifiable evidence of
disease."
-- From "Bulletin on the Rheumatic Diseases"; a Publication of the
ARTHRITIS
FOUNDATION; Vol.44, No.8, December 1995---- SIGAL
As Sigal was an author of this
http://www.acponline.org/lyme/calculator/
we wonder how helpful it is to use this
analytical method to discover the objective
source of the medical disorder for which the patient
seeks treatment?
Sigal has produced several articles on the immunological
effects of borreliosis, and these were mentioned previously
(anti-41, IL-1, etc)
Annu Rev Immunol 1997;15:63-92
Lyme disease: a review of aspects of its immunology and
immunopathogenesis.
Sigal LH.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9143682&dopt=Abstract
CYTOKINES AND THE BRAIN:
http://www.life.uiuc.edu/neuroscience/343/PDF/cytokines.pdf
http://bioinformatics.weizmann.ac.il/cytokine/news1_01/brain.html
The markers of illness, the markers identified
in borreliosis, the markers discussed by Lenny Sigal
do have an effect on affect and consciousness.
It's just not acceptable any more, to declare an
emerging clinical syndrome an emotional disorder.
In a time of bioweapons threats, is not sane health policy.
This is what the respectable researchers in the
field of mental disorders are doing:
http://www.scripps.edu/newsandviews/e_20021216/bloom2.html
It's real research. It's not lay media attention-seeking,
sensationalizing
behavior ("Antibiotics are Poison"). These people do not serve the
insurance industry.
===========
The Lyme vaccines were not qualified with a valid standard.
CDC Dearborn criteria are inaccurate, and the Dearborn meeting
was not a consensus meeting. "Lyme disease" is 5 of 10
band on a Western blot because this allowed the false
"qualification" of vaccines, and allowed allows for
denial of care, routinely, by those performing reviews
for insurance companies and in legal testimony:
http://www.geocities.com/HotSprings/Oasis/6455/conrail.txt
http://ourworld.compuserve.com/homepages/frankd/Sigal2.htm
We're tired of it. We would like him assessed for
his abilities to perform a valuable service in the
role of a "Healing Profession". The final insult had
had to be that he denies calling us "crazy".
http://ehpnet1.niehs.nih.gov/docs/2003/111-2/correspondence.html
"Nowhere in our article (Sigal and Hassett 2002) do we minimize or
devalue the pain or suffering of patients with chronic Lyme disease nor
do we state that such patients are "crazy" or "delusional." "
That's all he's ever done.
"Aporia. No way out, nothingness, or the impenetrable. It is something
which is not porous which cannot leak. The interlocutors in the early
Platonic dialogues cannot get out of the dead-ends into which Socrates
leads them. They are in aporia; hence, the locution "aporetic"
dialogues, the early dialogues where there seems to be no positive
result."
Kathleen Dickson
Instead of the Paul Ehrlich Museum, we'll put up a Lenny Sigal Museum of Medical Science and give him a new Disease catagory: MUPAs Medically Unexplained Physical Ailments. They'll actually be no displays in this museum, you just walk around looking at pictures of Lenny and push buttons to listen to him debate about Anxiety, Women and Fibromyalgia and the Role of Catatrophizing (actually maybe they can run an acting class for that one), How Women and Girls should never be told they actually have an illness because of their unnecessary waste/abuse of Healthcare Services, Munchausens, how antibiotics are actually poisons, (I think somehow those last two must go together...I just can't think of how...) ...
This whole Lenny Sigal Episode of Lyme History was INSANE.
====================
CRIMINAL: "MUNCHAUSEN'S" Lenny Sigal
